SynthesisFrontiers in cardiovascular medicine2025
Effect of HIIT on hemostasis and vascular stiffness: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Can resistance training alone or resistance training combined with aerobic training improve arterial stiffness, endothelial function, and other vascular function indicators in adults with hypertension or overweight/obesity-related vascular risk? A systematic review and meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2026Pooled it
- Optimal dosage of exercise combined with intermittent fasting for body composition and cardiometabolic health in adults: a systematic review and multilevel meta-analysis.Frontiers in nutrition · 2026Pooled it
- Effect of HIIT on hemostasis and vascular stiffness: a systematic review and meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2025Pooled it
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Several small randomized trials have examined the effects of high-intensity interval training (HIIT) on hemostasis and vascular stiffness. However, a clear consensus regarding these effects has not been established. The study is to systematically review the evidence and quantify the impacts of HIIT compared with moderate-intensity continuous training (MICT) or usual care (UC) on hemostasis and vascular stiffness. Methods: Randomized controlled trials (RCTs) exploring the impact of HIIT, MICT, or UC on hemostasis and vascular stiffness were retrieved from PubMed, Embase, Web of Science, and Cochrane databases up to June 10, 2025. A meta-analysis was performed to compare the standardized mean differences (SMD) of changes from baseline to post-intervention in platelet count (PLT), fibrinogen (FIB), D-dimer (D-D), carotid-femoral pulse wave velocity (cfPWV), augmentation index (AIx), AIx normalized to a heart rate of 75 beats·min Results: Overall, 68 RCTs involving 2,679 patients were included in the analysis. PLT [SMD (95% CI) = -0.26 (-0.51; -0.01)] and FIB [SMD (95% CI) = -0.60 (-1.18; -0.01)] in hemostasis were decreased. Decreased cfPWV [SMD (95% CI) = -0.22 (-0.38; -0.06)], AIx [SMD (95% CI) = -0.16 (-0.30; -0.02)], and AIx@75HR [SMD (95% CI) = -0.35 (-0.61; -0.10)], as well as increased FMD [SMD (95% CI) = 0.37 (0.02; 0.72)] were observed in vascular stiffness. However, there were no notable differences in the D-D and nFMD parameters. Conclusion: HIIT notably improved FIB, cfPWV, AIx, and FMD compared to MICT, or UC. Under certain conditions, PLT and AIx@75HR can also benefit from HIIT. It may be particularly advantageous for patients with cardiovascular disease. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/522614, identifier CRD42024522614.
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