Evidence map›Paper›PMID 40697964›Full record

ArticleBrain communications2025

Pupil-linked arousal, cortical activity, and cognition in Alzheimer's disease.

Michael C B David, Emma-Jane Mallas, Lucia M Li, Magdalena A Kolanko, Ramin Nilforooshan, Man Lai Tsoi, Hanim Karakoc, Karen Hoang, Johanna Brandt, Charikleia Triantafyllou and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Review
  4. Attenuated pupillary response during visual search in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Michael C B DavidUK Dementia Research Institute Care Research and Technology Centre, Imperial College London, London W12 0BZ, UK.ORCID https://orcid.org/0000-0002-8724-2840
Emma-Jane MallasUK Dementia Research Institute Care Research and Technology Centre, Imperial College London, London W12 0BZ, UK.ORCID https://orcid.org/0000-0002-4050-0208
Lucia M LiUK Dementia Research Institute Care Research and Technology Centre, Imperial College London, London W12 0BZ, UK.
Magdalena A KolankoUK Dementia Research Institute Care Research and Technology Centre, Imperial College London, London W12 0BZ, UK.
Ramin NilforooshanUK Dementia Research Institute Care Research and Technology Centre, Imperial College London, London W12 0BZ, UK.
Man Lai TsoiImperial College London, Brain Sciences, South Kensington, London SW7 2AZ, UK.
Hanim KarakocImperial College London, Brain Sciences, South Kensington, London SW7 2AZ, UK.
Karen HoangImperial College London, Brain Sciences, South Kensington, London SW7 2AZ, UK.
Johanna BrandtImperial College London, Brain Sciences, South Kensington, London SW7 2AZ, UK.
Charikleia TriantafyllouImperial College London, Brain Sciences, South Kensington, London SW7 2AZ, UK.
Dragos C GruiaUK Dementia Research Institute Care Research and Technology Centre, Imperial College London, London W12 0BZ, UK.
Darije CustovicUK Dementia Research Institute Care Research and Technology Centre, Imperial College London, London W12 0BZ, UK.
Peter J LallyUK Dementia Research Institute Care Research and Technology Centre, Imperial College London, London W12 0BZ, UK.ORCID https://orcid.org/0000-0003-0075-0103
Karl A ZimmermanUK Dementia Research Institute Care Research and Technology Centre, Imperial College London, London W12 0BZ, UK.
Care Research and Technology Group of the UK Dementia Research Institute
Paresh A MalhotraUK Dementia Research Institute Care Research and Technology Centre, Imperial College London, London W12 0BZ, UK.ORCID https://orcid.org/0000-0002-1897-0780
Gregory ScottUK Dementia Research Institute Care Research and Technology Centre, Imperial College London, London W12 0BZ, UK.
David J SharpUK Dementia Research Institute Care Research and Technology Centre, Imperial College London, London W12 0BZ, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arousal dysfunction contributes to impairments seen in Alzheimer's disease. However, the nature and degree of this dysfunction have not been studied in detail. We investigated changes in tonic and phasic arousal using simultaneous pupillometry-EEG, relating these changes to locus coeruleus integrity, a key arousal nucleus. Forty Alzheimer's disease participants and 30 controls underwent neuropsychological testing using the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), MRI designed to show contrast in the locus coeruleus as a measure of integrity and simultaneous pupillometry-EEG during 5 min of eyes-open resting-state. Pupillometry-EEG was then also applied during an oddball task which included a passive session and sessions in which responses to target stimuli were required, to test the effect of salience. Alzheimer's disease had lower locus coeruleus integrity (

Indexed as

attentionneuromodulationnoradrenalineoddballpupils

Identifiers

PMID40697964
PMCPMC12280328

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.