ArticleFrontiers in public health2025
Global, regional, and national burden and trends of syphilis among women of childbearing age from 1990 to 2021.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Re-emerging syphilis among women of reproductive age: temporal dynamics, demographic drivers, inequalities and projections to 2046.New microbes and new infections · 2026Article
- Review
- Quality and content analysis of syphilis-related short videos on Douyin (TikTok): A cross-sectional study.Digital healthArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Syphilis represents a significant sexual health concern for women of childbearing age (WCBA) worldwide. However, information regarded the burden and trends associated with this disease is limited. This study aimed to evaluate the changes in syphilis burden among WCBA aged 15-49 years from 1990 to 2021 at global, regional, and national levels. Methods: The extensive information was gathered from the Global Burden of Disease (GBD) 2021 database concerning the incidence, prevalence, and disability-adjusted life years (DALYs) related to syphilis in WCBA aged 15-49 across 204 countries and territories from 1990 to 2021. To quantify temporal trends, the estimated annual percentage change (EAPC) was calculated in age-standardized rate (ASR) for incidence, prevalence, and DALYs based on age group, region, and sociodemographic index (SDI). The relationship between ASR and SDI was examined using spearman correlation analysis. Results: In 2021, there were 20.48 million prevalent cases, 5.36 million new syphilis cases, and 39.59 thousand DALYs among WCBA, reflecting increases of 45.85, 46.96, and 16.08%, respectively, since 1990. Over 32 years, global rates of prevalence, incidence, and DALYs declined, with EAPCs of -0.50, -0.35, and -1.30. However, high-middle SDI regions experienced rising trends in incidence (EAPC: 0.28) and prevalence (EAPC: 0.22). The Low-middle SDI region had the highest syphilis cases among WCBA, accounting for about one-third of the global total. Notably, the 20-24 age group had the highest incidence rate at 467.35 per 100,000. Conclusion: Our findings highlight a decline in the global prevalence of syphilis from 1990 to 2021, the burden of this disease remains significant in low-and middle-income countries and regions. The development of more effective strategies to prevent and reduce the burden of syphilis is a pressing need.
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