Evidence map›Paper›PMID 40697822›Full record

ArticleFrontiers in cellular and infection microbiology2025

The host genes influencing

Yuxin Sun, Wenzhen Zhou, Senlin Ma, Qiuxin Lu, Yinuo Yuan, Yanchao Zheng, Yifan Yang, Kangshuai Zhou, Qingjiang Chen, Gonghao Sun and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuxin Sun *Department of Emergency, Huashan Hospital, Fudan University, Shanghai, China.
Wenzhen Zhou *Department of Emergency, Huashan Hospital, Fudan University, Shanghai, China.
Senlin Ma *Department of Emergency, Huashan Hospital, Fudan University, Shanghai, China.
Qiuxin LuDepartment of Emergency, Huashan Hospital, Fudan University, Shanghai, China.
Yinuo YuanDepartment of Emergency, Huashan Hospital, Fudan University, Shanghai, China.
Yanchao ZhengDepartment of Emergency, Huashan Hospital, Fudan University, Shanghai, China.
Yifan YangDepartment of Emergency, Huashan Hospital, Fudan University, Shanghai, China.
Kangshuai ZhouDepartment of Emergency, Huashan Hospital, Fudan University, Shanghai, China.
Qingjiang ChenDepartment of Emergency, Huashan Hospital, Fudan University, Shanghai, China.
Gonghao SunDepartment of Emergency, Huashan Hospital, Fudan University, Shanghai, China.
Zhaoming ShangDepartment of Emergency, Huashan Hospital, Fudan University, Shanghai, China.
Junwei QianDepartment of Emergency, Huashan Hospital, Fudan University, Shanghai, China.
Xiaofei JiangDepartment of Emergency, Huashan Hospital, Fudan University, Shanghai, China.
Mingquan ChenDepartment of Emergency, Huashan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: This study integrated summary-data-based Mendelian randomization (SMR) of cis-expression quantitative trait loci (cis-eQTLs) from blood, transverse colon, and sigmoid colon tissues with CDI genome-wide association study (GWAS) data to identify host genes influencing CDI susceptibility. Bayesian co-localization was employed to validate relationships. Then a germ-free (GF) mice model colonized with Results: SMR analysis identified 14 genes associated with CDI risk, primarily clustered in the major histocompatibility complex (MHC) region. Notably, THOC5 exhibited robust associations (P Discussion: These findings reveal key host genes, particularly THOC5, that influence susceptibility to CDI, providing new targets for future prevention and treatment research. Additionally, the study suggests a potential mechanism by which host intestinal LA protects against CDI, highlighting the interaction between probiotics and host transcriptional networks in CDI resistance. These insights offer valuable directions for further investigation.

Indexed as

Clostridioides difficileClostridium InfectionsHost-Pathogen InteractionsLactobacillus acidophilusAnimalsColonDisease Models, AnimalGastrointestinal MicrobiomeGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMendelian Randomization AnalysisMiceProbioticsQuantitative Trait LociClostridioides difficile infectiongut probioticslactobacillus acidophilusMendelian randomizationTHOC5 gene

Identifiers

PMID40697822
PMCPMC12279842

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.