Evidence map›Paper›PMID 40697816›Full record

ArticleFrontiers in cellular and infection microbiology2025

Plasma protein biomarkers of

Bernard N Kanoi, Harrison Waweru, Francis M Kobia, Joseph Mukala, Peter Kirira, Dominic Mogere, Radiosa Gallini, Mikael Åberg, Manu Vatish, Jesse Gitaka and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bernard N KanoiCentre for Malaria Elimination, Institute of Tropical Medicine, Mount Kenya University, Thika, Kenya.
Harrison WaweruCentre for Malaria Elimination, Institute of Tropical Medicine, Mount Kenya University, Thika, Kenya.
Francis M KobiaCentre for Malaria Elimination, Institute of Tropical Medicine, Mount Kenya University, Thika, Kenya.
Joseph MukalaSchool of Public Health, Mount Kenya University, Thika, Kenya.
Peter KiriraSchool of Pure and Applied Sciences, Mount Kenya University, Thika, Kenya.
Dominic MogereSchool of Public Health, Mount Kenya University, Thika, Kenya.
Radiosa GalliniDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Mikael ÅbergDepartment of Medical Sciences, Clinical Chemistry and SciLifeLab Affinity Proteomics, Uppsala University, Uppsala, Sweden.
Manu VatishNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom.
Jesse GitakaCentre for Malaria Elimination, Institute of Tropical Medicine, Mount Kenya University, Thika, Kenya.
Masood Kamali-MoghaddamDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Pregnant women in sub-Saharan Africa face heightened susceptibility to Methods: Here, we used the high throughput proximity extension assay to screen plasma from malaria-exposed pregnant women for differentially expressed proteins that may serve as candidate biomarkers of Results: Using proximity extension assay (PEA), we identified elevated IgG Fc receptor IIb (FCGR2B) and heme oxygenase-1 (HO-1) in malaria-positive pregnancies, while neurturin (NRTN) and IL-20 were downregulated. Discussion: IL-20 emerged as a top candidate biomarker, warranting validation in large cohorts with placental histopathology.

Indexed as

BiomarkersBlood ProteinsMalaria, FalciparumPregnancy Complications, ParasiticAdultFemaleHeme Oxygenase-1High-Throughput Screening AssaysHumansPlacentaPlasmodium falciparumPregnancyProteomicsYoung AdultBiomarkersBlood ProteinsHeme Oxygenase-1biomarkersmalaria in pregnancyPlasmodium falciparumpregnancy-associated malariaproteomicsproximity extension assay (PEA)

Identifiers

PMID40697816
PMCPMC12279802

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.