Evidence map›Paper›PMID 40697804›Full record

ArticleNeurotrauma reports2025

Effects of Acute Probenecid Administration on Histopathological and Functional Outcomes after Spinal Cord Injury in Rats.

Toru Asari, Sunao Tanaka, Damien D Pearse, Juan Pablo de Rivero Vaccari, Toshitada Sawada, Yasuyuki Ishibashi, Robert W Keane, W Dalton Dietrich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Toru AsariDepartment of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA.
Sunao TanakaDepartment of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA.
Damien D PearseDepartment of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA.
Juan Pablo de Rivero VaccariDepartment of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA.
Toshitada SawadaDepartment of Orthopaedic Surgery, Takaoka Seishikai Hospital, Takaoka, Japan.
Yasuyuki IshibashiDepartment of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Robert W KeaneDepartment of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
W Dalton DietrichDepartment of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA.ORCID https://orcid.org/0000-0002-8732-4942

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) triggers an inflammatory response that is partially mediated by the inflammasome and the production of pro-inflammatory cytokines. We have previously shown that pannexin-1 is involved in the activation of the inflammasome, and that probenecid inhibits this caspase-1-mediated inflammatory process. In this study, we employed an

Indexed as

inflammasomePannexin-1probenecidspinal cord injury

Identifiers

PMID40697804
PMCPMC12281109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.