ReviewCurrent research in food science2025
Carrier design based on zein: From the perspectives of multi-molecule encapsulation, probiotic encapsulation, and application standards.
Review in Current research in food science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Protein-Based Probiotic Delivery Systems: Structural Basis, Functional Roles, and Food Applications.Comprehensive reviews in food science and food safety · 2026Review
- Recent Advances in Polysaccharide-Based Encapsulation of Probiotics: Encapsulation Technologies, Material Properties, and Applications in Dairy Products.Foods (Basel, Switzerland) · 2026Review
- Polymer-Based and Biomaterial Encapsulation of Probiotics for Improved Viability.Probiotics and antimicrobial proteins · 2026Review
- Encapsulation of probiotics to improve their survival: A focus onFood chemistry: X · 2026Review
- Holistic concept guided quality control of traditional Chinese medicines for optimizing bioavailability.Chinese medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zein is an excellent carrier material for active substances. Previous reviews have mainly focused on the encapsulation of single active molecules, while this review is for the first time to comprehensively review the design of multi-molecules and probiotics carriers, and summarize its application standards. For multi-molecule encapsulation, zein nanoparticles with core-shell structure are widely used. Based on the difference in fabrication methods and physicochemical properties of active molecules, zein nanoparticles were categorized into mixed/isolated encapsulation. Besides, zein microparticles and Pickering emulsions (with two-compartment structures for different active molecules) stabilized by zein nanoparticles as multi-molecule delivery platforms are also discussed. For carrier design of probiotics, the methods include layer-by-layer self-assembly/complex coacervation based on zein nanoparticles, microcapsules, emulsion, and probiotic biofilm formation based on zein fibers. Importantly, zein has different criteria in the food/pharmaceutical industry, which is a prerequisite for practical application. Although zein-based multi-molecule carriers have been studied extensively, most of the current work focuses on characterizing properties instead of mechanism investigation of complex systems. In the future, designing carriers with superior structures to control the release rate of different molecules and targeted colonic delivery of probiotics are the main challenges for expanding zein applications. This review is expected to guide the rapid and scientific progress of zein-based carrier design for multi-molecules and probiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.