ReviewJournal of oral biology and craniofacial research
Biological copper levels in oral squamous cell carcinoma: A meta-analysis with insights into disease progression and prognosis.
Review in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Background: Oral squamous cell carcinoma (OSCC) is a common, aggressive cancer characterized by frequent local invasion, metastasis, and recurrence. Previous research has reported altered copper levels in OSCC; however, studies employed different methods to assess these levels, leading to inconsistent or inaccurate measurements. This variability impacts the evaluation of copper's potential as a biomarker in OSCC. Aim: This systematic review and meta-analysis aimed to evaluate copper concentrations in serum, saliva, and tissue of OSCC patients compared to healthy controls and explore its potential association with disease progression and prognosis. Method: ologyA comprehensive search across electronic databases identified 147 studies, with 18 meeting the inclusion criteria following full-text screening. Data from 751 OSCC patients and 628 healthy controls were analysed. A random-effects meta-analysis was employed to compute standardized mean differences (SMD). Subgroup analyses based on sample type and analytical technique were performed. Risk of bias was assessed using established quality checklists. Results: Serum copper levels were significantly higher in OSCC patients (SMD: 2.22 μg/ml; I Conclusion: Copper concentrations are significantly elevated in OSCC across serum and saliva. However, current evidence does not support its role as a prognostic biomarker. Standardized, prospective studies are warranted.
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