ArticleFrontiers in nutrition2025
Transcriptomic and metabolomic insights into the synergistic effects of resveratrol and β-hydroxy-β-methylbutyric acid on hepatic function under varying protein diets in Tibetan sheep.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Increasing evidence indicated resveratrol (RES) and β-hydroxy-β-methylbutyric acid (HMB) regulated several biological processes via modulating gene expression. This study employed transcriptomic and metabolomic analyses to investigate the impact of RES and HMB supplementation, in combination with varying dietary protein levels on hepatic immunity, antioxidant capacity, and morphology in Tibetan sheep. Methods: Two treatments (with or without RES and HMB supplementation) and two dietary protein levels (12% vs. 14% of the basal diet) were tested according to a 2 × 2 factorial arrangement within a Latin square design. A total of 120 healthy two-month-old male Tibetan lambs (16.87 ± 0.31 kg) were randomly allocated for 90-day feeding experiment, with the following treatments: low-protein basal diet without (L group) or with (L-RES + HMB group) supplemental 1.50 g/d RES and 1.25 g/d HMB, and high-protein basal diet without (H group) or with (H-RES + HMB group) supplemental 1.50 g/d RES and 1.25 g/d HMB. Results: The results indicated that the liver tissue structure was predominantly normal in the H-RES + HMB group, devoid of central vein congestion. The catalase (CAT) activity and total antioxidant (T-AOC) capacity were significantly increased when fed the 14% protein diet ( Conclusion: Dietary protein level and RES/HMB supplementation exhibited positively interaction effect on immunity and antioxidant capacity. The 14% protein diet with RES and HMB improved the hepatic function through modulating the gene and metabolite in Tibetan sheep.
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