Evidence map›Paper›PMID 40697522›Full record

ArticleBiochemistry and biophysics reports2025

Co-loaded simvastatin-ginsenoside Rh2 liposomes enhance cellular immune responses as vaccine adjuvants.

Yinxiu Huang, Qingqing Nie, Zhijie Chen, Wang Gong, Wenqiang Cao, Xue Wang, Yanna Liu, Ziyan Meng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yinxiu HuangSchool of Modern Agricultural and Forestry Engineering, Ganzhou Polytechnic College, Ganzhou, Jiangxi Province, China.
Qingqing NieKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Provincial Department of Education, School of Animal Science, Ganzhou Polytechnic College, Ganzhou, Jiangxi Province, China.
Zhijie ChenKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Provincial Department of Education, School of Animal Science, Ganzhou Polytechnic College, Ganzhou, Jiangxi Province, China.
Wang GongKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Provincial Department of Education, School of Animal Science, Ganzhou Polytechnic College, Ganzhou, Jiangxi Province, China.
Wenqiang CaoKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Provincial Department of Education, School of Animal Science, Ganzhou Polytechnic College, Ganzhou, Jiangxi Province, China.
Xue WangKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Provincial Department of Education, School of Animal Science, Ganzhou Polytechnic College, Ganzhou, Jiangxi Province, China.
Yanna LiuKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Provincial Department of Education, School of Animal Science, Ganzhou Polytechnic College, Ganzhou, Jiangxi Province, China.
Ziyan MengKey Laboratory of Green and Healthy Livestock and Poultry Breeding Technology of Jiangxi Provincial Department of Education, School of Animal Science, Ganzhou Polytechnic College, Ganzhou, Jiangxi Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccine adjuvants are pivotal in novel vaccine development, enhancing immunization and modulating immune responses. This study prepared liposomes loaded with simvastatin and ginsenoside Rh2 (LIPO-SIM-Rh2) via high-speed shearing, rotary evaporation, and high-pressure homogenization. Using C57BL/6J mice, six groups were established to explore its immune-enhancing effects and mechanisms. Following two-dose immunization at 0 and 21 days, IgG antibody titers (ELISA), immune cell responses (flow cytometry), and safety/function of antigen-presenting cells (pathological sections, immunofluorescence staining) were detected. Results showed LIPO-SIM-Rh2 had a stable dispersion and a near-100 % encapsulation efficiency. Compared with other groups, it significantly increased anti-OVA specific IgG titer, promoted cellular immune response, up-regulated MHC-I molecule antigen presentation pathway, activated macrophages, promoted dendritic cell homing, and caused no obvious damage or inflammation to major organs. In conclusion, LIPO-SIM-Rh2 adjuvant has a feasible preparation method and strong immune-enhancing potential for vaccines.

Indexed as

AdjuvantCellular immunitiesGinsenoside Rh2LiposomeSimvastatinVaccine

Identifiers

PMID40697522
PMCPMC12282209

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