Evidence map›Paper›PMID 40697517›Full record

ReviewCancer pathogenesis and therapy2025

Advances in nanoparticle-mediated cancer therapeutics: Current research and future perspectives.

V C Deivayanai, P Thamarai, S Karishma, A Saravanan, P R Yaashikaa, A S Vickram, R V Hemavathy, R Rohith Kumar, S Rishikesavan, S Shruthi

Abstract readReview
In one paragraph

Review in Cancer pathogenesis and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Potential of Nanoparticle-Based Phototherapies for Future Treatment of Uveal Melanoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Article
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  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
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  14. Article
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

V C DeivayanaiDepartment of Biotechnology, Saveetha School of Engineering, SIMATS, Thandalam, Chennai, 602105, India.
P ThamaraiDepartment of Biotechnology, Saveetha School of Engineering, SIMATS, Thandalam, Chennai, 602105, India.
S KarishmaDepartment of Biotechnology, Saveetha School of Engineering, SIMATS, Thandalam, Chennai, 602105, India.
A SaravananDepartment of Biotechnology, Saveetha School of Engineering, SIMATS, Thandalam, Chennai, 602105, India.
P R YaashikaaDepartment of Biotechnology, Saveetha School of Engineering, SIMATS, Thandalam, Chennai, 602105, India.
A S VickramDepartment of Biotechnology, Saveetha School of Engineering, SIMATS, Thandalam, Chennai, 602105, India.
R V HemavathyDepartment of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai, 602015, India.
R Rohith KumarDepartment of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai, 602015, India.
S RishikesavanDepartment of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai, 602015, India.
S ShruthiDepartment of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai, 602015, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One in six deaths worldwide is caused by cancer, making it a major global health concern. Despite their effectiveness, traditional treatment approaches such as radiation therapy, chemotherapy, and surgery frequently have negative side effects and high costs. New approaches, such as gene therapy, are promising but are hampered by high costs and accessibility problems. Nanoparticles (NPs) facilitate targeted drug delivery by leveraging passive targeting mechanisms, such as the enhanced permeability and retention (EPR) effect, and by actively targeting surfaces with ligands for site-specific binding through the functionalization of surfaces. This approach enhances therapeutic results while lowering off-target toxicities. Notably, chemotherapeutic medications, immunotherapeutic agents, and photothermal therapies can now be delivered more precisely to the affected site using NP-based systems. By boosting particularity, reducing side effects, and tackling drug resistance, nanomedicine has the potential to revolutionize cancer treatment and ultimately advance personalized oncological care. These advancements highlight the possibilities for field growth, and future development regulations are detailed.

Indexed as

CancerChemotherapyDrug deliveryNanomedicineTherapeuticsToxicity

Identifiers

PMID40697517
PMCPMC12277815

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.