Evidence map›Paper›PMID 40697511›Full record

ArticleCancer pathogenesis and therapy2025

Expert consensus on a multidisciplinary approach for the management of multiple myeloma-related bone disease.

Yutong Wang, Qiming Xu, Yuan Li, Yongbin Su, Ling Wang, Xiaoquan Wang, Jian Ge, Hongmei Jing, Yuxing Guo, Yalin Chen and 50 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer pathogenesis and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Harnessing cuproptosis: a new avenue for targeted cancer therapies.Apoptosis : an international journal on programmed cell death · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

60 authors.

Yutong WangDepartment of Hematology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100031, China.
Qiming XuDepartment of Orthopedic Oncology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100031, China.
Yuan LiDepartment of Orthopedic Oncology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100031, China.
Yongbin SuDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100031, China.
Ling WangDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100031, China.
Xiaoquan WangDepartment of Rehabilitation, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100031, China.
Jian GeDepartment of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.
Hongmei JingDepartment of Hematology, Peking University Third Hospital, Beijing 100191, China.
Yuxing GuoDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Yalin ChenDepartment of Radiotherapy, Peking University People's Hospital, Beijing 100044, China.
Xianan LiDepartment of Radiotherapy, Peking University People's Hospital, Beijing 100044, China.
Jun-Ling ZhuangDepartment of Hematology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Jing TanDepartment of Hematology, The Third People's Hospital of Chengdu, Chengdu, Sichuan 610031, China.
Xiaobo WangDepartment of Hematology, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116023, China.
Liye ZhongDepartment of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, China.
Jun LuoDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Peng ZhaoDepartment of Hematology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
Shengjin FanDepartment of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, China.
Jinhai RenDepartment of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, China.
Haiping YangDepartment of Hematology, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan 471000, China.
Heng MeiInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Chunyan SunInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Chunrui LiDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Xuemei SunDivision of Hematology, Department of Medicine, Jiangsu Provincial Traditional Chinese Medical Hospital, Nanjing, Jiangsu 210023, China.
Xuechun LuDepartment of Hematology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Guangxun GaoDepartment of Hematology, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi 710032, China.
Zeping ZhouDepartment of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650504, China.
Yaozhu PanDepartment of Hematology, The 940th Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, Gansu 730050, China.
Ying SunDepartment of Hematology, Chifeng Municipal Hospital, Chifeng, Nei Monggol 024000, China.
Zhang HongDepartment of Hematology, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, Shandong 271000, China.
Zhiqiang LiuShandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China.
Yanping MaDepartment of Hematology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Yi WangDepartment of Hematology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, China.
Wei SunDepartment of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Jian HouDepartment of Hematology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Jianqing MiDepartment of Hematology, Shanghai Institute of Hematology, National Research Center for Translational Medicine, State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Wenming ChenDepartment of Hematology, Myeloma Research Center of Beijing, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Xiaobing HuangDepartment of Hematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.
Bingzong LiDepartment of Hematology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.
Rong FuDepartment of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Jumei ShiDepartment of Hematology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, China.
Xuehong RanDepartment of Hematology, Weifang People's Hospital, The First Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261041, China.
Fuling ZhouDepartment of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
Aili HeDepartment of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.
Min MaoDepartment of Hematology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region 830001, China.
Zhen CaiBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, China.
Nan LiDepartment of Orthopedics, Forth Medical Center of PLA General Hospital 100048, Beijing, China.
Meng XuDepartment of Orthopedics, Forth Medical Center of PLA General Hospital 100048, Beijing, China.
Xiaojing YanDepartment of Hematology, First Hospital of China Medical University, Shenyang, Liaoning 110001, China.
Wei YangDepartment of Hematology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110055, China.
Gang AnState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Lihua GongDepartment of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Lichao SunState Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhihong LiDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Tang LiuDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Yanjuan HeDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China.
Junqiang YinDepartment of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Yao LiuDepartment of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing 400044, China.
Weifeng LiuDepartment of Orthopedic Oncology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100031, China.
Li BaoDepartment of Hematology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100031, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This consensus on multiple myeloma-related bone diseases (MBDs) underscores the importance of a multidisciplinary approach that encompasses hematology, radiology, orthopedics, and additional specialties to tackle its intricate challenges. MBD, a prevalent and debilitating complication of multiple myeloma, leads to bone pain, fractures, and skeletal-related events (SREs), which profoundly impact patients' quality of life. The guidelines offer a thorough framework for diagnosis, treatment, and continual assessment, emphasizing early detection and consistent monitoring using imaging techniques such as positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI). Treatment strategies prioritize the careful application of anti-myeloma agents, bisphosphonates, and denosumab to minimize bone loss and decrease SRE risk, complemented by surgical and radiotherapy interventions for structural or pain-related issues. Supportive care measures, including pain management, rehabilitation, nutritional support, and dental evaluations, play a crucial role in enhancing patient outcomes and preserving quality of life. This consensus advocates a standardized, evidence-based approach to managing MBD, ensuring comprehensive and coordinated care for patients.

Indexed as

Bone diseaseDiphosphonatesMultiple myelomaOrthopedicsQuality of lifeRecommendationTherapeutic effect

Identifiers

PMID40697511
PMCPMC12277822

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.