Evidence map›Paper›PMID 40697510›Full record

ArticleCancer pathogenesis and therapy2025

Efficacy and safety of camrelizumab plus

Tengfei Zhang, Kang Cui, Xiaodan Liu, Yikai Han, Lin Li, Jinhui Xie, Xiangwen Dong, Yuhan Bao, Shengju Ren, Ziwen Lei and 4 more

Abstract read
In one paragraph

Article in Cancer pathogenesis and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tengfei ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Kang CuiDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Xiaodan LiuDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Yikai HanDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Lin LiThe First Clinical Medical School, Zhengzhou University, Zhengzhou, Henan 450000, China.
Jinhui XieThe First Clinical Medical School, Zhengzhou University, Zhengzhou, Henan 450000, China.
Xiangwen DongThe First Clinical Medical School, Zhengzhou University, Zhengzhou, Henan 450000, China.
Yuhan BaoThe First Clinical Medical School, Zhengzhou University, Zhengzhou, Henan 450000, China.
Shengju RenThe First Clinical Medical School, Zhengzhou University, Zhengzhou, Henan 450000, China.
Ziwen LeiThe First Clinical Medical School, Zhengzhou University, Zhengzhou, Henan 450000, China.
Pu YuDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Huan ZhaoDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Yabing DuDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Wang MaDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Esophageal cancer (EC) is the seventh most prevalent cancer and the sixth most common cause of cancer-related mortalities worldwide. Camrelizumab, a monoclonal antibody, has demonstrated moderate efficacy in esophageal squamous cell carcinoma (ESCC). Methods: This single-arm, single-center, exploratory trial was conducted at the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Eligible patients received 200 mg camrelizumab biweekly and two bags of Results: From May 2020 to October 2022, ten patients with advanced ESCC who did not respond to first-line therapy were admitted. At the data cutoff date (August 9, 2023), the median follow-up duration was 12 months. Two of 10 (20%) achieved objective responses. The median survival was 7.5 months and the median OS was not reached. Grade 3 treatment-related AEs occurred in two of the 10 patients (20%). No serious treatment-related AEs or deaths occurred. Conclusions: Camrelizumab combined with Trial registration: ChiCTR2000032093, https://www.chictr.org.cn.

Indexed as

CamrelizumabEsophageal squamous cell carcinomaImmunotherapyLacticaseibacillus paracasei

Identifiers

PMID40697510
PMCPMC12277836

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.