Evidence map›Paper›PMID 40697508›Full record

ReviewCancer pathogenesis and therapy2025

Immunomodulatory potential of dexmedetomidine in perioperative pain management for patients with cancer.

Yuxian Liu, He Ma, Xintong Wang, Isabelle Yang, Jingping Wang

Abstract readReview
In one paragraph

Review in Cancer pathogenesis and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuxian LiuPhillips Academy, Andover, MA 01810, USA.
He MaDepartment of Anesthesia, The Second Hospital of Jilin University, Changchun, Jilin 130021 China.
Xintong WangDepartment of Anesthesia, Shenzhen Children's Hospital, Shenzhen, Guangdong 518172, China.
Isabelle YangDepartment of Anesthesia, Critical Care and Pain Management, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Jingping WangDepartment of Anesthesia, Critical Care and Pain Management, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

•Dexmedetomidine (DEX) has immunomodulatory effects in perioperative pain management.•DEX can reduce pro-inflammatory cytokines.•DEX has dose-dependent effects on tumor progression.•Optimizing DEX dosing may improve the therapeutic outcomes of cancer surgery.•Further research is needed to clarify DEX's impact on cancer recurrence and survival, as the findings remain mixed.

Identifiers

PMID40697508
PMCPMC12277841

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.