ArticleIBRO neuroscience reports2025
The nitrergic mechanism of geraniol in PTZ-induced seizures.
Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- From gastric to neuroprotection: pantoprazole mitigates epilepsy via TrkB/BDNF and KCC2 modulation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: This investigation aims to elucidate the role of NO in the anticonvulsant effects of Geraniol (GER) using a mouse model of pentylenetetrazole (PTZ)-induced seizures. Methods: Mice were allocated into ten groups, including a control group receiving normal saline. The treatment groups received GER (10, 20, 30, and 40 mg/kg), L-NAME (10 mg/kg), L-arginine (L-arg) at 150 mg/kg, a sub-effective dose of GER (10 mg/kg) combined with L-NAME, and an effective dose of GER (40 mg/kg) plus L-arg, respectively. All drugs were administered Results: GER prolonged the seizure threshold and reduced serum and PFC nitrite levels. Also, it downregulated the gene expression of Conclusion: GER exhibits anticonvulsant properties by modulating the nitrergic system, increasing seizure latency, and reducing NO production. This suggests its potential as a therapeutic candidate for seizure management.
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