ArticleJournal of Brown hospital medicine2025
Powassan Virus-Related Encephalitis in the Off-Season: A Case Report.
Article in Journal of Brown hospital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Powassan Virus in the United States: An AI-Integrative One Health Scoping Review of Ecological Drivers, Zoonotic Interactions, Symptom Profiles, and Public Health Implications.Infectious disease reports · 2026Review
- Pathogens of the human central nervous system-the major viral pathogens.Journal of neurovirology · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arboviral infections, increasingly identified due to the effects of climate change, pose significant health risks. We present a case of meningoencephalitis due to Powassan (tick-borne Flavivirus) virus in a middle-aged man from Rhode Island, unexpectedly diagnosed in the winter season. Confirmatory plaque reduction neutralization testing (Centers for Disease Control) revealed elevated titers for Powassan virus >1:20,480. The cerebrospinal fluid analysis demonstrated lymphocytic pleocytosis. The case highlights the expanding seasonal and geographic range of arboviruses, necessitating year-round vigilance. No targeted therapies exist; management remains supportive as 40-60% of patients develop chronic sequelae, including persistent confusion, fatigue, and headache. Arboviral etiologies in patients with altered mentation must be prioritized on the differential, even outside of peak transmission seasons.
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