Evidence map›Paper›PMID 40697486›Full record

ArticleBiological psychiatry global open science2025

White Blood Cell Proportions Are Associated With Response to Psychosocial Therapy in Young People at Ultra-High Risk for Psychosis.

Lauren F Barker, Allan F McRae, Hok Pan Yuen, Anjali K Henders, Leanne M Wallace, Tian Lin, Christina Phassouliotis, Jessica Spark, Melissa Kerr, Enda M Byrne and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lauren F BarkerInstitute for Molecular Bioscience, The University of Queensland, Saint Lucia, Queensland, Australia.
Allan F McRaeInstitute for Molecular Bioscience, The University of Queensland, Saint Lucia, Queensland, Australia.
Hok Pan YuenOrygen, Parkville, Victoria, Australia.
Anjali K HendersInstitute for Molecular Bioscience, The University of Queensland, Saint Lucia, Queensland, Australia.
Leanne M WallaceInstitute for Molecular Bioscience, The University of Queensland, Saint Lucia, Queensland, Australia.
Tian LinInstitute for Molecular Bioscience, The University of Queensland, Saint Lucia, Queensland, Australia.
Christina PhassouliotisOrygen, Parkville, Victoria, Australia.
Jessica SparkOrygen, Parkville, Victoria, Australia.
Melissa KerrOrygen, Parkville, Victoria, Australia.
Enda M ByrneChild Health Research Center, The University of Queensland, Saint Lucia, Queensland, Australia.
G Paul AmmingerOrygen, Parkville, Victoria, Australia.
Barnaby NelsonOrygen, Parkville, Victoria, Australia.
Naomi R WrayInstitute for Molecular Bioscience, The University of Queensland, Saint Lucia, Queensland, Australia.
Patrick D McGorryOrygen, Parkville, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: White blood cell (WBC) counts, DNA methylation, and gene expression are reported to be associated with psychosis. However, it is not known whether these associations precede the onset of psychosis or whether they are relevant for the stratification of psychosis risk in clinically high-risk individuals. The STEP (Staged Treatment in Early Psychosis) clinical trial evaluated the effectiveness of a sequential intervention strategy for preventing psychosis in a cohort of young people at ultra-high risk (UHR) of psychosis. Participants were assessed for remission of UHR status after up to 6 months of treatment with psychosocial therapy. Methods: Cell-type proportions estimated from whole-blood DNA methylation samples ( Results: Baseline lymphocyte cell proportions (odds ratio [OR], 0.23; 95% CI, 0.07-0.62; Conclusions: Our results indicate the potential importance of WBCs for further stratification of psychosis risk in UHR individuals and reinforce the importance of routine collection of WBC data for future clinical trials.

Indexed as

Clinical trialDNA methylationGene expressionLymphocytesNeutrophil-lymphocyte ratioRemission

Identifiers

PMID40697486
PMCPMC12281354

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.