Evidence map›Paper›PMID 40697439›Full record

ArticleAnnals of gastroenterology

Oral vancomycin is associated with less therapy intensification in adults with symptomatic inflammatory bowel disease and underlying primary sclerosing cholangitis.

Chiraag Kulkarni, Sarah Talamantes, Abhishek Dimopoulos-Verma, Touran Fardeen, Samir Khan, George Cholankeril, George Triadafilopoulos, Sidhartha R Sinha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chiraag KulkarniDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Palo Alto, California, USA (Chiraag Kulkarni, Sarah Talamantes, Abhishek Dimopoulos-Verma, Touran Fardeen, Sidhartha R. Sinha).
Sarah TalamantesDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Palo Alto, California, USA (Chiraag Kulkarni, Sarah Talamantes, Abhishek Dimopoulos-Verma, Touran Fardeen, Sidhartha R. Sinha).
Abhishek Dimopoulos-VermaDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Palo Alto, California, USA (Chiraag Kulkarni, Sarah Talamantes, Abhishek Dimopoulos-Verma, Touran Fardeen, Sidhartha R. Sinha).
Touran FardeenDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Palo Alto, California, USA (Chiraag Kulkarni, Sarah Talamantes, Abhishek Dimopoulos-Verma, Touran Fardeen, Sidhartha R. Sinha).
Samir KhanSection of Gastroenterology and Hepatology, Department of Medicine, Baylor University, Houston, Texas, USA (Samir Khan, George Cholankeril).
George CholankerilSection of Gastroenterology and Hepatology, Department of Medicine, Baylor University, Houston, Texas, USA (Samir Khan, George Cholankeril).
George TriadafilopoulosDepartment of Gastroenterology, Hepatology, and Nutrition, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (George Triadafilopoulos).
Sidhartha R SinhaDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Palo Alto, California, USA (Chiraag Kulkarni, Sarah Talamantes, Abhishek Dimopoulos-Verma, Touran Fardeen, Sidhartha R. Sinha).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Case reports describe the use of oral vancomycin therapy (OVT) in adult patients with concomitant symptomatic inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC). OVT is associated with a higher likelihood of IBD remission in pediatric IBD-PSC patients. However, there are limited data on the association between OVT and IBD disease course in adult IBD-PSC patients. Methods: We retrospectively evaluated IBD therapy intensification in adults with IBD-PSC prescribed OVT at 2 centers. Subjects were stratified by time "on" and "off" OVT. Only those who spent a minimum of 12 months in each period were included. The primary outcome was the frequency of IBD therapy intensification events. Results: Of 31 patients initially considered, 22 met the inclusion criteria. Most patients (68.2%) had fewer or no intensification events while "on OVT" compared to those "off OVT". OVT was associated with fewer therapy intensification events (1.7 vs. 6.7, P=0.021) and steroid prescriptions (0.6 vs. 3.2, P=0.013) per 10 person-years. Conclusions: OVT use is associated with less need for IBD therapy intensification in symptomatic IBD-PSC adult patients. Prospective trials of OVT in such patients are warranted.

Indexed as

disease activityInflammatory bowel diseaseoral vancomycin therapyprimary sclerosing cholangitis

Identifiers

PMID40697439
PMCPMC12277516

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.