ArticleOncology letters2025
A novel defined manganese metabolism-related gene signature for predicting the prognosis of pancreatic ductal adenocarcinoma.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Trace Elements in the Pancreas: From Physiological Homeostasis to the Pathogenesis of Diabetes, Pancreatitis, and Cancer-A Review.Life (Basel, Switzerland) · 2026Review
- Development and validation of manganese metabolism-related genes prognostic model in colorectal cancer and its immunological characteristics.Journal of gastrointestinal oncology · 2026Article
- Integrating bulk RNA-seq and ScRNA-seq to identify manganese metabolism-related subtypes and immunoregulatory mechanisms in liver hepatocellular carcinoma.Open life sciences · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) represents a particularly aggressive and highly malignant neoplasm, characterized by its unfavorable prognosis and restricted treatment alternatives. The present study aimed to use bioinformatics methodologies to assess transcriptomic data sourced from The Cancer Genome Atlas and the Gene Expression Omnibus to pinpoint biomarkers associated with manganese metabolism that may forecast outcomes in PDAC. Utilizing differential expression analysis, Least Absolute Shrinkage and Selection Operator regression and multivariable Cox regression, 12 essential genes were identified that demonstrate notable associations with the prognosis of PDAC (Natriuretic Peptide A, Kynureninase, Integrin Subunit β6, Cytochrome P450 Family 27 Subfamily A Member 1, C-X-C Motif Chemokine Ligand 10, Protein Phosphatase 2 Regulatory Subunit Bβ, MET Proto-Oncogene Receptor Tyrosine Kinase, Matrix Metalloproteinase 3, Keratin 19, ATPase Na
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