Evidence map›Paper›PMID 40697326›Full record

ArticleToxicology reports2025

Acute toxicological evaluation of bone-targeted parathyroid hormone-related peptide (PTHrP) antagonist to inhibit breast cancer metastases to bone.

Tulasi Ponnapakkam, Muralidharan Anbalagan, Robert E Stratford, Binghao Zou, Robert Blair, Brian G Rowan, Robert Gensure

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tulasi PonnapakkamXavier University of Louisiana, New Orleans, LA 70125, USA.
Muralidharan AnbalaganDepartment of Structural And Cellular Biology, Tulane University, School of Medicine, New Orleans, LA 70112, USA.
Robert E StratfordIncyte Corporation, Willmington, DE 19803, USA.
Binghao ZouDepartment of Structural And Cellular Biology, Tulane University, School of Medicine, New Orleans, LA 70112, USA.
Robert BlairTulane University, National Primate Research Center, Covington, LA 70433 USA.
Brian G RowanDepartment of Structural And Cellular Biology, Tulane University, School of Medicine, New Orleans, LA 70112, USA.
Robert GensureDartmouth Health Children's, Geisel School of Medicine, Lebanon, NH 03756, USA.

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
NIH HHS P51 OD011104
6 · The paper itself

Abstract

The present study evaluates the

Indexed as

Bone metastasesBreast cancerCollagen Binding DomainDrug developmentParathyroid HormonePTHrP antagonistTargeted therapyToxicity

Identifiers

PMID40697326
PMCPMC12281181

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.