Evidence map›Paper›PMID 40697267›Full record

ArticleAccess microbiology2025

Gummatous mitral valve endocarditis from tertiary syphilis.

Nisha George, Daniel Pan, Shirley Sze, Caroline Williams, Zein El-Dean, Victor Zlocha, Elizabeth Webb, Manish Pareek

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Access microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nisha GeorgeDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
Daniel PanDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
Shirley SzeLeicester NIHR Biomedical Research Centre, Leicester, UK.
Caroline WilliamsDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
Zein El-DeanDepartment of Cardiothoracic Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Victor ZlochaDepartment of Cardiothoracic Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Elizabeth WebbDepartment of Histopathology, University Hospitals of Leicester NHS Trust, Leicester, UK.
Manish PareekDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0003-1521-9964

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 50-year-old Romanian gentleman presented with fever, myalgia and 30 kg weight loss. He was treated for syphilis after acquiring it 16 years ago. On examination, there was a pansystolic murmur in the axilla, and the patient had an ataxic gait. Blood tests showed raised inflammatory markers. However, standard investigations for infective endocarditis, including multiple blood cultures, serological titres for fastidious organisms and antibody tests were negative. A computed tomography (CT) of the chest, abdomen and pelvis demonstrated hepatosplenomegaly with multiple splenic infarcts. A magnetic resonance imaging (MRI) of the head with contrast showed multiple punctate enhancement in the bilateral hemispheres with leptomeningeal enhancement. Transthoracic echocardiogram demonstrated a large vegetation leading to severe mitral regurgitation. Serum treponemal antibodies were positive;

Indexed as

gummamitral endocarditissyphilitic endocarditistertiary syphilis

Identifiers

PMID40697267
PMCPMC12281932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.