ArticleWorld journal of gastrointestinal oncology2025
Genetic evidence for the causal influence of inflammatory factors on intrahepatic cholangiocarcinoma risk.
Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Bidirectional Mendelian randomization analysis reveals significant associations between Serum DNA repair proteins and liver cancer.Cancer biomarkers : section A of Disease markersArticle
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Authors and funding
6 authors.
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Abstract
backgroundIntrahepatic cholangiocarcinoma (ICC) is a highly malignant liver cancer subtype with limited effective treatment options. Emerging evidence suggests that inflammatory factors play a critical role in ICC progression within the tumor microenvironment (TME). However, causal relationships between specific inflammatory factors and ICC risk remain unclear.
aimTo investigate the causal relationship between inflammatory factors and ICC.
methodsThis study used Mendelian randomization (MR) and Bayesian weighted MR (BWMR) analyses to investigate the causal impact of inflammatory factors on ICC risk. Genetic data from genome-wide association studies were utilized to identify and validate instrumental variables for 91 inflammatory factors, followed by sensitivity analyses to ensure robustness.
resultsMR analysis identified significant associations between elevated levels of artemin and matrix metalloproteinase (MMP)-10 and increased ICC risk. BWMR and meta-MR analysis results validated these associations. Sensitivity analyses confirmed the stability of these findings, indicating that specific inflammatory factors may contribute causally to ICC development.
conclusionThis study provides evidence that certain inflammatory factors, particularly artemin and MMP-10, are causally linked to ICC risk, identifying them as potential risk factors and therapeutic targeting. These findings enhance the understanding of the inflammatory components of the TME in ICC, supporting the development of targeted intervention strategies.
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