Evidence map›Paper›PMID 40697236›Full record

ArticleWorld journal of gastrointestinal oncology2025

Flap endonuclease-1 promotes pancreatic cancer progression

Yu Xia, Na Guo, Cheng-Lou Zhu, Jie-Yun Gao, Ming-Xu Da

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yu XiaThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Na GuoThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Cheng-Lou ZhuThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Jie-Yun GaoDepartment of Clinical Teaching, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China.
Ming-Xu DaThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, Gansu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPancreatic cancer (PC) remains one of the most lethal malignancies. While flap endonuclease-1 (FEN1) has been implicated in various cancers, its role in PC remains unclear.

aimTo investigate the biological functions and mechanisms of FEN1 in PC progression.

methodsFEN1 expression and its prognostic significance were analyzed using Gene Expression Omnibus, The Cancer Genome Atlas, and Genotype-Tissue Expression databases. FEN1 was knocked down or overexpressed in PC cell lines using lentiviral vectors. Cell proliferation, migration, and invasion were assessed

resultsFEN1 was significantly upregulated in PC tissues and correlated with poor prognosis. FEN1 promoted PC cell proliferation, migration, and invasion

conclusionFEN1 functions as an oncogenic driver in PC progression

Indexed as

AKT/mTOR signaling pathwayFlap endonuclease-1InvasionMigrationPancreatic cancerProliferation

Identifiers

PMID40697236
PMCPMC12278205

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.