ArticleWorld journal of gastrointestinal oncology2025
Nav1.6 drives colorectal cancer proliferation and invasion through MAPK signaling pathway.
Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A network toxicology and machine learning approach to uncover the molecular machinery of bisphenol A-induced colorectal cancer.Scientific reports · 2026Article
- Global, regional, and national burden of gastric cancer attributable to diet high in sodium from 1990 to 2021.Frontiers in nutrition · 2025Article
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Authors and funding
9 authors.
Funding
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Abstract
backgroundVoltage-gated sodium channels (VGSCs, or Navs) are highly expressed in various tumors and play a critical role in tumor metastasis and invasion.
aimTo identify Nav1.6-associated cancer genes through bioinformatics analysis and experimental validation, with the goal of determining the role of Nav1.6 in colorectal cancer (CRC) metastasis.
methodsThe Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data were analyzed using weighted correlation network analysis (WGCNA) and Venn analysis to identify Nav1.6-associated genes in CRC. siRNA, real-time PCR, and western blotting were employed to validate the Nav1.6-associated cancer genes and signaling pathways identified in CRC. Cell counting kit-8 and Transwell migration assays were used to assess the proliferation and migration of CRC cells.
resultsThe analysis of TCGA and GEO datasets, along with WGCNA, identified 575 differentially expressed genes associated with
conclusionThese findings suggest that Nav1.6 promotes CRC cell proliferation and invasion which is related to the MAPK signaling pathway.
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