ArticleWorld journal of gastrointestinal oncology2025
Adult pancreatoblastoma: Systematic review of the literature and case report of a young adult patient.
Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAdolescent/adult pancreatoblastoma (PB) is an uncommon malignant pancreatic tumor. The paucity of data stemming from the rarity of this disease leads to minimal generalized guidelines regarding its diagnosis and treatment. There is a limited number of case reports in the literature and there has been no recent analysis of the literature to consolidate their common features. The purpose of the featured study is to review the available cases of adolescent/adult PB and analyze the common genetic features, histologic features, treatment regimens, tumor sizes, tumor locations, and areas of metastasis to advance ongoing research and better understand and treat this rare condition.
aimTo present a patient case and systematically review all available cases in the literature to consolidate the common physical, genetic, and histologic features of PB.
methodsThis is a systematic review of the literature with a case study. A total of 89 patient cases were discovered in the literature database for adolescent/adult PB, all of which were reviewed and are included in our research. Patients aged 16-18 were considered adolescent and patients aged greater than 18 were considered adult. Adolescents and adults were grouped together for the purpose of this study. The patient from the case report was seen in a community hospital setting.
resultsThe 89 cases analyzed from the literature were found in 51 references (our case report included), which were consolidated into the six categories mentioned above. A plurality of references reports PB in the head of the pancreas, 4.0-10.0 cm in size, and with the most common site of metastasis to the liver. Histology studies most commonly included acinar groups, squamous corpuscles/nests, cytokeratin, chromogranin, trypsin, chymotrypsin, and synaptophysin. Genetic studies most commonly included adenomatous polyposis coli, B-cell lymphoma/leukemia 10, catenin beta 1, and Wnt/beta-catenin mutations. The mainstay of treatment was surgery with chemotherapy typically including cisplatin, carboplatin, doxorubicin, 5 fluorouracil, mitomycin, bleomycin, gemcitabine, and vindesine. Radiation was also often used.
conclusionCommon pancreatoblastoma features include acinar groups, chromogranin, chymotrypsin, squamous corpuscles, synaptophysin and trypsin on histology and adenomatous polyposis coli, B-cell lymphoma/leukemia 10, catenin beta 1, and Wnt/beta-catenin genetic mutations.
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