Evidence map›Paper›PMID 40697101›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

A Scalable Fishbone Nanowire Array (FINE) for 3D Quasi-Intracellular Recording in Intact Brains.

Youngbin Tchoe, Jihwan Lee, Karen J Tonsfeldt, Tianhai Wu, Daniel R Cleary, Hoi Sang U, Ren Liu, Guy Bouvier, Ritwik Vatsyayan, Andrew M Bourhis and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Youngbin TchoeIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-7807-5318
Jihwan LeeIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Karen J TonsfeldtIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Tianhai WuIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Daniel R ClearyIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Hoi Sang UIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Ren LiuIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Guy BouvierDepartment of Physiology, University of California San Francisco, San Francisco, CA, 94143, USA.
Ritwik VatsyayanIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Andrew M BourhisIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Sang Heon LeeIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Eric HalgrenDepartment of Radiology, University of California San Diego, La Jolla, CA, 92093, USA.
Ian GaltonDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Massimo ScanzianiDepartment of Neurological Surgery, University of California San Diego, La Jolla, CA, 92093, USA.
Shadi A DayehIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-1756-1774

Funding

Thin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of EpilepsyUG3NS123723 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2021 to 2025
$9.5M
Integrated Biophysical and Neural Model of Electrical Stimulation EffectsR01NS109553 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAZHENOV, MAKSIM V, HALGREN, ERIC · 2019 to 2023
$4.4M
Bringing Light to Functional Mapping in Resective NeurosurgeryDP2EB029757 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2019 to 2019
$2.4M
Integration of High Definition Display Technologies with Platinum Nanorod Microelectrodes for Large Scale in-vivo Recording and StimulationR01NS123655 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2021 to 2021
$2.0M
Functional Mapping of the Suprachiasmatic NucleusK99NS119291 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TONSFELDT, KAREN JILL · 2022 to 2023
$296k
National Nanotechnology Coordinated InfrastructureNational Research Foundation of Korea RS-2024-00351532National Science Foundation 5R01NS109553National Science Foundation ECCS1542148National Science Foundation UG3NS123723NIBIB NIH HHS DP2 EB029757NIBIB NIH HHS DP2-EB029757NINDS NIH HHS K99 NS119291NINDS NIH HHS K99NS119291NINDS NIH HHS R01 NS109553NINDS NIH HHS R01 NS123655NINDS NIH HHS UG3 NS123723San Diego Nanotechnology Infrastructure
6 · The paper itself

Abstract

Intracellular recordings provide unique access to the submillisecond neuronal membrane potential changes, revealing dynamics that orchestrate cellular, local, and large-scale brain activity. However, technical requirements limit the scalability of intracellular recordings to large populations of neurons, especially within intact brains. To overcome this limitation, a Fishbone Intracellular Nanowire Electrode (FINE) is developed with ultra-sharp nanowire tips strategically integrated at slanted angles along an implantable shank to record 3D intracellular potentials from ensembles of neurons in intact brain. A novel fabrication process is developed to integrate reverse-angled platinum silicide (PtSi) nanowires to preserve the structural integrity of FINE during insertion. As-implanted or sub-micron retraced FINE spreads the PtSi nanowires away from the shank to establish intimate nanowire-neuron interfaces that yield quasi-intracellular potentials. Comparative analyses of nanowire recordings versus adjacent planar recordings on the same shank validate their distinctive quasi-intracellular recording characteristics. The scalability of FINE is demonstrated to a 3D 24-shank array with 594 nanowires and 430 planar contacts and successfully identified quasi-intracellular potentials across 127 distinct nanowires in the intact brain. FINE's 3D quasi-intracellular recording holds the potential to unlock detailed investigations of the intricate ionic potential fluctuations and patterns of transmembrane potentials that drive behavior and cognition.

Indexed as

BrainNanowiresAnimalsMembrane PotentialsNeuronsPlatinumPlatinumelectrophysiologyintact brainintracellularnanowirerecording

Identifiers

PMID40697101
PMCPMC13221790

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.