Evidence map›Paper›PMID 40696900›Full record

ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2025

Real-world functional outcomes and predictors of futile recanalization in patients meeting criteria for SELECT2.

Rahul R Karamchandani, Liang Wang, Hongmei Yang, Dale Strong, Jeremy B Rhoten, Jonathan D Clemente, Gary Defilipp, Nikhil M Patel, Joe D Bernard, William R Stetler and 15 more

Abstract read
In one paragraph

Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Rahul R KaramchandaniDepartment of Neurology, Neurosciences Institute, Wake Forest University School of Medicine, Atrium Health, Charlotte, NC, USA.ORCID 0000-0002-2111-5523
Liang WangClinical Quality Analytics, Atrium Health, Charlotte, NC, USA.
Hongmei YangClinical Quality Analytics, Atrium Health, Charlotte, NC, USA.
Dale StrongClinical Quality Analytics, Atrium Health, Charlotte, NC, USA.
Jeremy B RhotenDepartment of Neurology, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.
Jonathan D ClementeCharlotte Radiology, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.
Gary DefilippCharlotte Radiology, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.
Nikhil M PatelDepartment of Internal Medicine, Pulmonary and Critical Care, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.
Joe D BernardCarolina Neurosurgery and Spine Associates, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.
William R StetlerCarolina Neurosurgery and Spine Associates, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.
Jonathan M ParishCarolina Neurosurgery and Spine Associates, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.ORCID 0000-0002-9634-6406
Andrew U HinesCharlotte Radiology, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.
Shraddha T PatelDepartment of Neurology, Neurosciences Institute, Wake Forest University School of Medicine, Atrium Health, Charlotte, NC, USA.
Kasser SabaDepartment of Neurology, Neurosciences Institute, Wake Forest University School of Medicine, Atrium Health, Charlotte, NC, USA.
Tamour TareenDepartment of Neurology, Neurosciences Institute, Wake Forest University School of Medicine, Atrium Health, Charlotte, NC, USA.
Harsh N PatelDepartment of Neurology, Neurosciences Institute, Wake Forest University School of Medicine, Atrium Health, Charlotte, NC, USA.
Satheesh K BokkaDepartment of Neurology, Neurosciences Institute, Wake Forest University School of Medicine, Atrium Health, Charlotte, NC, USA.
Lauren MackoDepartment of Neurology, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.
Anna Maria HelmsDepartment of Neurology, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.ORCID 0000-0001-7353-6779
Katelynn J TeliDepartment of Neurology, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.
Elizabeth A AdelmanDepartment of Neurology, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.
Laura WilliamsDepartment of Neurology, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.
Julia RetelskiDepartment of Neurology, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.
Stacey Q WolfeDepartment of Neurological Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0001-7603-2728
Andrew W AsimosDepartment of Emergency Medicine, Neurosciences Institute, Atrium Health, Charlotte, NC, USA.ORCID 0000-0002-6697-3724

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundRecent randomized trials have shown that patients presenting with large core infarctions benefit from endovascular thrombectomy compared to medical management. We report real-world outcomes and factors associated with futile recanalization in patients meeting large core criteria for SELECT2.MethodsRetrospective review of health system records from 1/1/2024 to 12/31/2024 for patients presenting with computed tomography (CT) Alberta Stroke Program Early CT Score (ASPECTS) 3-5 or CT perfusion (CTP) core infarction ≥50 milliliters. Primary and secondary outcomes, 90-day modified Rankin Scale (mRS) score 0-2 and 0-3, respectively, were compared to rates reported in SELECT2. Logistic regression was used to identify factors independently associated with 90-day mRS 5-6 despite successful reperfusion (modified treatment in cerebral ischemia 2b-3).ResultsAmong 59 patients with 90-day outcome data, median CT ASPECTS and CTP core were 7 (5-10) and 78.5 (57-119) mL, respectively. Twelve (20.3%) achieved mRS 0-2, while 18 (30.5%) were ambulatory (mRS 0-3). Recanalization was achieved in 51 subjects, of whom 27 (52.9%) had a devastating neurological outcome (mRS 5-6). Atrial fibrillation was the only factor independently associated with futile recanalization (odds ratio 13.5, 95% confidence interval 1.4-128.8,

Indexed as

large coreStrokethrombectomy

Identifiers

PMID40696900
PMCPMC12286990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.