ArticleThe Journal of organic chemistry2025
One-Pot Metal-Free Synthesis of Diarylamines from Aromatic Aldehydes and Anilines.
Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A novel and environmentally friendly method has been developed for the synthesis of a broad range of diarylamines from inexpensive and readily available starting materials, such as aromatic aldehydes and amines. The process follows a one-pot strategy in which imine formation is succeeded by an oxidative rearrangement analogous to the Meinwald reaction and concludes with a light-induced deformylation step. This efficient transformation proceeds in a single vessel with a high atom economy under mild, metal-free conditions. The methodology was further demonstrated as a key step in the synthesis of phentolamine, a reversible, nonselective α-adrenergic blocker used in the treatment of hypertensive emergencies.
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