SynthesisInternational wound journal2025
Risk Factors for First-Ever Diabetes-Related Foot Ulcer: A Systematic Review and Meta-Analysis.
Synthesis in International wound journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Less Is More? Physical Inactivity and Increased Risk of Diabetes-Related Foot Ulceration-A Systematic Review.Diabetes/metabolism research and reviews · 2026Pooled it
- [Practical guideline on the prevention and management of diabetic foot in China (Ⅰ)].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Guideline
- Risk Factors for First-Ever Diabetes-Related Foot Ulcer: A Systematic Review and Meta-Analysis.International wound journal · 2025Pooled it
- Clinical Performance of the IWGDF Risk Stratification System for Diabetic Foot Ulceration: A Gender-Disaggregated Study of 713 Patients.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Article
- Article
- Decapping scavenger enzyme as a promising biomarker in diabetic foot ulcers: A need for cautious interpretation.World journal of diabetes · 2026Article
- Screening practices and risk factors for diabetic foot complications among patients with diabetes at a tertiary centre in Riyadh, Saudi Arabia.Journal of family medicine and primary care · 2026Article
- Healing Outcomes in Diabetic Foot Ulcers Managed Within a Structured Multidisciplinary Care Model: A Retrospective Study.Journal of diabetes research · 2026Article
- A Review on Recent Progress and Clinical Translation of Self-Assembled Hydrogels in Diabetic Wound Repair.International journal of nanomedicine · 2026Review
- Predictors of Unfavorable Outcomes in Diabetic Foot Ulcers.Diagnostics (Basel, Switzerland) · 2025Article
- Mechanisms of lncRNA in Diabetic Foot Ulcer Wound Healing.The journal of gene medicine · 2025Review
- Practical guidelines for the prevention and management of diabetic foot disease in China.Burns & trauma · 2025Article
- Relationship between serum LDH levels and diabetic peripheral neuropathy in type 2 diabetic patients.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
We aimed to systematically review and quantify risk factors for first-ever diabetes-related foot ulcer (DFU). Four English and three Chinese electronic databases were searched for cohort and case-control studies reporting risk factors for first-ever DFU. Two researchers independently screened titles, abstracts and full text, extracted data and assessed the quality of included studies. Meta-analyses were performed for risk factors reported in at least two studies, using unadjusted odds ratios and standardised mean differences for dichotomous and continuous variables. Of 6736 potential studies screened, 23 were included in the meta-analysis and 24 in the systematic review. Twenty-eight significant risk factors for first-ever DFU were identified, including older age, obesity, male gender, unmarried status, alcohol consumption, current smoking, insufficient physical activity, longer diabetes duration, increased HbA1c, fasting plasma glucose, creatinine and triglyceride, decreased eGFR and high-density lipoprotein, high vibration perception threshold, albuminuria, low ankle-brachial pressure index ratio, cardiovascular, cerebrovascular and peripheral artery disease, retinopathy, nephropathy, neuropathy, myocardial infarction, foot deformity, skin dryness, insulin treatment and anti-hypertensive treatment. This study provides the first comprehensive synthesis of risk factors for first-ever DFU. Identifying high-risk individuals based on these factors can enhance early intervention strategies, reducing the burden of DFU in diabetes management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.