Trial reportAnaesthesiology intensive therapy2025
Effect of preoperative intranasal dexmedetomidine on characteristics of spinal anesthesia with hyperbaric bupivacaine for lower limb orthopedic surgery: a double-blinded randomized control study.
Trial report in Anaesthesiology intensive therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
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Abstract
introductionDexmedetomidine is administered intravenously, intrathecally, and intramuscularly to enhance the effect of subarachnoid anesthesia. In this study, we investigated the effect of intranasal dexmedetomidine on the characteristics of spinal anesthesia. MATERIAL AND
methodsIn this double-blinded randomized control study, 60 patients undergoing orthopedic surgery under spinal anesthesia were allocated to two groups. Group A received intranasal dexmedetomidine 1 μg kg
resultsThe onset of sensory block and motor block did not differ significantly between the groups. However, two-segment regression time was significantly longer in Group A than in Group B (113.17 ± 14.11 min vs. 94.13 ± 9.59 min, respectively;
conclusionsIntranasal dexmedetomidine prolongs the effect of subarachnoid anesthesia, provides stable hemodynamics with arousable sedation, and offers a noninvasive, better-tolerated alternative compared to other invasive routes of administration.
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