ArticleDiabetes/metabolism research and reviews2025
Combined Associations of Type 2 Diabetes and Peripheral Neuropathy With Device-Measured Physical Activity and Sedentary Behaviour-The Maastricht Study.
Article in Diabetes/metabolism research and reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Development and Validation of a Machine Learning-Based Predictive Model for Peripheral Neuropathy Risk in Elderly Patients with Type 2 Diabetes.Risk management and healthcare policy · 2026Article
- Combined Associations of Type 2 Diabetes and Peripheral Neuropathy With Device-Measured Physical Activity and Sedentary Behaviour-The Maastricht Study.Diabetes/metabolism research and reviews · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
objectivePeripheral neuropathy (PN) is a common complication of type 2 diabetes mellitus (T2DM). In this study, we determined the independent and combined associations of T2DM and PN with device-based measures of physical activity levels and sedentary behaviour. MATERIALS AND
methodsCross-sectional data from The Maastricht Study were used (N: 6471, age 59.8 ± 8.8). T2DM was determined with an oral glucose tolerance test and PN was, using a neurothesiometer, defined as an impaired vibration perception threshold (iVPT), that is exceeding 25 V in either one or both halluces. Physical activity and sedentary behaviour outcomes were derived through 8 days of activPAL accelerometer measurement, worn 24 h/day. Multiple linear regression analyses were used with adjustment for demographic, lifestyle and health-related indicators.
resultsIn the fully adjusted model, the combined presence of T2DM and iVPT presented the lowest step count (-1407 steps/day [95% CI: -1851, -963]), and showed the lowest time in light-intensity (-27.2 min/day [-38.6, -15.8]) and moderate-to-vigorous physical activity (-9.5 min/day [-12.6, -6.5]). Moreover, those with both conditions had the highest sedentary time (+33.3 min/day [21.4, 45.2]) and longest sedentary bout durations (+1.0 min/bout [0.6, 1.4) compared with those without these conditions. DISCUSSION: T2DM and PN were both independently associated with lower levels of physical activity and higher levels of sedentary time. The combination of T2DM with PN was associated with particularly low levels of physical activity and higher levels of sedentary time, indicating an additive association. Strategies to improve physical activity in these individuals should address both conditions.
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