ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
The MR1/MAIT cell axis impacts the gut-brain axis through both cognition and microbial community structure in 5XFAD mice.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The MR1/MAIT cell axis impacts the gut-brain axis through both cognition and microbial community structure in 5XFAD mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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7 authors.
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Abstract
introductionMucosal-associated invariant T (MAIT) cells recognize microbial antigens presented by major histocompatibility complex class I-like molecule (MR1) and are elevated in Alzheimer's disease (AD) model mouse brains; MAIT cell-deficient AD mice have reduced brain pathology, supporting the importance of the gut-brain axis in AD. How the MR1/MAIT cell axis impacts cognition and the microbiome remains unknown.
methodsNovel object recognition/placement, Y-maze, and Barnes maze were used to determine memory changes in wild-type (WT), MR1 KO, 5XFAD, and 5XFAD/MR1 KO mice. Fecal samples were analyzed using 16S rRNA gene amplicon sequencing.
results5XFAD/MR1KO mice did not display the cognitive deficits observed in 5XFAD. There were relative abundance differences in the fecal microbiota between 5XFAD and 5XFAD/MR1 KO mice, and male 5XFAD/MR1 KO mice had increased microbiome alpha diversity compared to 5XFAD mice. DISCUSSION: Our data suggest that the MR1/MAIT cell axis negatively affects cognition and impacts gut microbiome diversity. These results further support a detrimental role for the MR1/MAIT cell axis in AD. HIGHLIGHTS: 5XFAD mice lacking major histocompatibility complex, class I-related (MR1) and mucosal-associated invariant T (MAIT) cells had no deficits in recognition memory. Compared to 5XFAD, there was improved learning in the Barnes maze by female 5XFAD/MR1 knock-out (KO) mice. There was an increased abundance of Campylobacterota in male 5XFAD/MR1 KO versus 5XFAD mice. Six of nine linear discriminant analysis effect size-identified distinguishing features were higher in 5XFAD/MR1 KO mice.
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