SynthesisBrain and behavior2025
Association Between Irisin Level and Cognitive Function: A Systematic Review and Meta-Analysis.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Exercise-associated changes in leptin and irisin relate to cognitive function in older adults stratified by cognitive impairment.Scientific reports · 2026Article
- Irisin as a Regulator of Brain Energy Homeostasis: Implications for Age-Related Neurodegenerative Diseases.Cells · 2026Review
- Protective Role of Physical Exercise and Exercise-Induced FNDC5/Irisin in Combating Diabetes-Related Cognitive Impairment and Autonomic and Peripheral Neuropathies: A Comprehensive Review.Journal of diabetes research · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundIrisin is a newly discovered muscle factor, and more and more research has focused on the association between irisin and brain function. Our study aimed at investigating the correlation between irisin level and cognition.
methodsFive electronic databases were searched for the correlation between irisin level and cognition in humans. The primary outcome was the correlation between irisin level and global cognition. Secondary outcomes were the correlation between irisin level and each cognitive domain, the correlation between brain-derived neurotrophic factor (BDNF) level and global cognition, and the correlation between irisin level and BDNF level. Correlation coefficient (r) was used as effect size with its 95% confidence intervals (CI).
resultsThere were a total of 11 articles that reported the correlation between irisin level and global cognition, and the pooled result showed a positive correlation among them (r = 0.26, 95% CI: 0.10-0.41). The subgroup analysis showed a positive correlation among non-Asians (r = 0.28, 95% CI: 0.16-0.40), studies with small sample size (r = 0.35, 95% CI: 0.20-0.49), irisin measured from both serum (r = 0.32, 95% CI: 0.15-0.49) and cerebrospinal fluid (r = 0.27, 95% CI: 0.03-0.50), scales using Mini-Mental State Examination (MMSE) (r = 0.36, 95% CI: 0.16-0.52), and study populations with diseases impairing cognition (r = 0.26, 95% CI: 0.07-0.43). Besides, our results indicated that there were no correlations between irisin level and cognitive domains, including immediate memory, short-term memory, executive function, attention, language, and visual spatial ability (all p > 0.05). Additionally, the results suggested a positive correlation between BDNF level and global cognitive function (r = 0.27, 95% CI: 0.12-0.42), as well as the correlation between irisin level and BDNF level (r = 0.41, 95% CI: 0.24-0.56).
conclusionsThis study implied that irisin has a positive effect on cognitive function, and the mechanism may be associated with promoting the expression of BDNF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.