Observational studyMedicine2025
Investigating the association between calcium-phosphorus balance and osteoarthritis: Evidence from NHANES 2007-2016.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The role of the calcium-phosphorus balance in influencing osteoarthritis (OA) risk is not fully understood. This study investigated the relationship between calcium-phosphorus metabolism and OA risk. Data from the National Health and Nutrition Examination Survey spanning 2007 to 2016 were used in this study. Participants aged ≥ 30 years with available serum calcium and phosphorus levels, self-reported OA status, and relevant covariates were included in the study. Multivariable logistic regression analysis was performed to assess the potential influence of calcium-phosphorus metabolism on the risk of OA. Nonlinear relationships were assessed using the restricted cubic spline model. Participants with OA had mildly elevated calcium and phosphorus levels. Concurrently, the calcium-phosphorus (Ca/P) ratio decreased. With confounders adjusted for, the Ca/P ratio was inversely associated with OA risk (odds ratio (OR) = 0.72, 95% CI: 0.56-0.94, P = .017), while serum calcium (OR = 2.12, 95% confidence interval (CI): 0.96-4.68, P = .064) and phosphorus (OR = 1.87, 95% CI: 1.22-2.86, P < .01) were positively associated. The relationship between the Ca/P ratio and risk of OA was significantly influenced by body mass index (P for interaction < .05). The restricted cubic spline model indicated that the Ca/P ratio was nonlinearly associated with OA risk with a threshold of 1.96. Serum calcium level was associated with OA in a U-shaped pattern, with a threshold of 2.35. In contrast, a linear association was observed between serum phosphorus levels. A reduced Ca/P ratio, increased serum phosphorus, and either elevated or decreased serum calcium each contribute to a heightened risk of OA. Imbalances in calcium-phosphorus metabolism may be associated with osteoarthritis risk. Relevant biomarkers, such as serum calcium, phosphorus, and the Ca/P ratio, could serve as potential indicators. Further studies are needed to confirm these findings.
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Registered trials
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