SynthesisMedicine2025
Efficacy and safety of tacrolimus versus cyclophosphamide therapy for Henoch-Schönlein purpura nephritis in children: A systematic review.
Synthesis in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Telitacicept for childhood HSPN: A prospective self-controlled study.Clinical rheumatology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
backgroundThis systematic review studied and compared the safety and efficacy of glucocorticoids (GCs) + cyclophosphamide (CTX) and GCs + tacrolimus (TAC) therapies for treating children with Henoch-Schönlein purpura nephritis (HSPN).
methodsThe data on GCs + CTX and GCs + TAC therapies for HSPN children were procured from the EMbase, China National Knowledge Infrastructure, the Cochrane Library, PubMed, and Wanfang from the inception to May 10, 2024.
resultsThis review included 5 studies (2 non-randomized and 3 randomized controlled trials), comprising 363 patients. Furthermore, the complete remission within 6 months in the TAC group (43.3%) was higher than that in CTX group (26.2%) and the total remission within 6 months in the TAC (76.7%) was higher than that in CTX groups (54.1%). Moreover, in terms of adverse reactions, the incidence of hypertension in TAC group was higher than that in CTX group, whereas the incidences of other adverse reactions such as liver function injury, hyperglycemia, myelosuppression and gastrointestinal discomfort in TAC group were lower than that in CTX group.
conclusionThis systematic review indicated that for HSPN children, the TAC therapy may have relatively higher remission rate and fewer adverse reactions than the CTX therapy.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.