Observational studyMedicine2025
Morphometric effectiveness of calcium hydroxylapatite application in zygomatic and malar area on correction of nasolabial folds.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to investigate the indirect effects of calcium hydroxylapatite (CaHA) injections in the zygomatic and malar regions on the healing of nasolabial folds (NLFs). Given the anatomical complexity and proximity of the nasolabial area, selecting appropriate techniques for CaHA applications is crucial to prevent potential complications. The study is designed to contribute insights into the safety and efficacy of injections, aiming to enhance patient outcomes and minimize risks in aesthetic applications. This retrospective single-center study analyzed the effectiveness of CaHA injections in the zygomatic and malar regions for correcting NLFs in 51 female participants aged between 30 and 55. Images from clinical archives were used, taken before the application and 6 months after the application. The primary outcomes were evaluated using Gabor filter analysis, Global Aesthetic Improvement Scale, and Wrinkle Severity Rating Scale, complemented by morphometric measurements using Image J 1.52a software. Measurements before and 6 months after the application revealed significant improvements in NLF length: from 2.59 ± 0.64 cm to 2.24 ± 0.53 cm on the right side and from 2.76 ± 0.81 cm to 2.59 ± 0.61 cm on the left side. This corresponds to an improvement of 13.51 % and 6.16%, respectively. Evaluations using the Wrinkle Severity Rating Scale, Global Aesthetic Improvement Scale scores, and Gabor filter analysis also demonstrated positive NLF depth post-treatment changes. The results of our study indicate that CaHA injections in the zygomatic and malar regions lead to an indirect improvement in NLFs. Furthermore, our study provides standardized quantitative methods that can be used to assess the effectiveness of treatments in the nasolabial area. These analyses offer reliable tools for evaluating aesthetic procedures and provide valuable contributions to clinical practice.
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