Evidence map›Paper›PMID 40696601›Full record

ArticleMedicine2025

Salvianolic acid A inhibits the activation and aggregation of platelets in patients with acute coronary syndrome.

Peipei Wang, Shunqiong Zhang, Xinyuan Li, Shuanglin Xie, Yibin Mei, Wei Zhang, Abdullah A I Mamun, Wenjuan Lu, Taoqing Liang, Chunlai Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peipei WangDepartment of Cardiology, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang Province, China.
Shunqiong ZhangDepartment of Cardiology, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang Province, China.
Xinyuan LiDepartment of Cardiology, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang Province, China.
Shuanglin XieDepartment of Cardiology, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang Province, China.
Yibin MeiDepartment of Cardiology, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang Province, China.
Wei ZhangDepartment of Cardiology, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang Province, China.
Abdullah A I MamunCentral Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang Province, China.
Wenjuan LuDepartment of Cardiology, Shaoxing University, Shaoxing, Zhejiang Province, China.
Taoqing LiangDepartment of Cardiology, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang Province, China.
Chunlai ZengDepartment of Cardiology, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang Province, China.ORCID 0009-0004-2599-5654

Funding

Public Welfare Technology Research Funding Project of Zhejiang 2024SJZC126
6 · The paper itself

Abstract

backgroundThe acute blockage in coronary arteries further causes acute coronary syndrome (ACS). There are 2 main factors implicated in the activation and aggregation of platelets. However, this present study aimed to investigate the effect of salvianolic acid A (SAA) on the platelets in patients with ACS and explore its potential mechanism of action.

methodsThe impact of SAA on platelets under different stimulation conditions was studied using flow cytometry and platelet aggregation detection techniques.

resultsThe results demonstrated that in 40 ACS patients, ex vivo treatment of platelets with SAA (0.1 mg/ml) significantly reduced aggregation and activation. Intriguingly, we found no significant difference between the 3 types of ACS patients in the antiplatelet effect of SAA. Moreover, the results indicated that C-reactive protein, alanine aminotransferase, C-reactive protein-to-albumin ratio, total cholesterol, and low-density lipoprotein levels were negatively correlated with the anti-platelet effect of SAA in ACS patients and that a history of smoking may reduce the anti-platelet effect of SAA in the same group.

conclusionIn summary, the above findings of this study highlight the therapeutic potential of SAA against platelets in patients with ACS, providing new insights into clinical treatment and experimental research.

Indexed as

Acute Coronary SyndromeBlood PlateletsCaffeic AcidsLactatesPlatelet ActivationPlatelet AggregationPlatelet Aggregation InhibitorsAgedC-Reactive ProteinFemaleHumansMaleMiddle AgedCaffeic AcidsC-Reactive ProteinLactatesPlatelet Aggregation Inhibitorssalvianolic acid Aacute coronary syndromeCD62pPAC-1platelet activationplatelet aggregation ratesalvianolic acid A

Identifiers

PMID40696601
PMCPMC12282686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.