ArticleMedicine2025
Association between Sjögren syndrome and osteoporosis: A bidirectional Mendelian randomization study.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
This Mendelian randomization (MR) study aimed to investigate the relationships between Sjögren syndrome (SS) and osteoporosis (OP). We selected genetic instruments for predisposition to SS on published genome-wide association studies. Using a two-sample MR approach, we assessed association SS and OP. The random effects inverse variance weighting method was used as the primary analysis method, and the weighted median method, MR-Egger, weighted mode, and simple mode were used as supplementary analytical methods. Sensitivity analysis was performed using the heterogeneity test, the pleiotropy test, and the leave-one-out test. SS was notably associated with the presence of OP (odds ratio: 1.191; 95% confidence interval: 1.084-1.309; P < .005), but OP was not a susceptible factor for SS. This study suggested that from a genetic point of view, the SS was indeed a risk factor for OP. Furthermore, no significant causal effect of OP on SS was observed, indicating the absence of reverse causality between SS and OP.
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