ArticleMedicine2025
Molecular docking analysis of inhibitory effect of phytochemicals present in Yogaraja Guggulu on inflammation - implication in adjunctive management of radiation mucositis of oral cavity: An experimental study.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadiotherapy is one of the gold standards of cancer management and oral mucositis is a common adverse effect of radiation therapy. Radiation mucositis is mediated by inflammasomes such as nucleotide-binding domain, Lucin rich containing family pyrin domain-containing 3 (NLRP-3), NLRP-6, NLRP-12, interferon-inducible protein (AIM-2), and inflammatory mediators such as interleukin 1 beta (IL1-β). Although there are several strategies for management of the condition, traditional medicines with anti-inflammatory properties such as Yogaraja Guggulu has been less explored. The study was conducted to assess if phytochemicals of Yogaraja Guggulu could target NLRP-3, NLRP-6, NLRP-12, AIM-2, IL1-β, and thereby its role in adjunctive management of radiation-induced oral mucositis.
methodsPreparation of protein structures was done with retrieved 3D structures of target proteins (NLRP-3, NLRP-6, NLRP-12, AIM, and IL1-β) from the protein data bank (PDB) after which water molecules were removed and conversion of protein coordinates to PDBQT format was done with using python prescription virtual screening tool (PyRx). For the preparation of ligand structures, 25 phytochemical compounds from Yogaraja Guggulu were selected based on Lipinski's rule of 5 and retrieval of ligand structures in spatial data file format was done with PubChem Compound Database. PyRx (AutoDock Vina) tools to conduct docking studies. Postdocking analyses were done with Discovery Studio Biovia 2017 to analyze binding sites, hydrogen-bond interactions, hydrophobic interactions, and bonding lengths.
resultsThe results showed that the phytochemicals had a high affinity for these target proteins, suggesting potential anti-inflammatory effects.
conclusionYogaraja Guggulu may be a useful adjunct in the management of radiation-induced oral mucositis due to its anti-inflammatory properties.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.