ReviewRecent advances in drug delivery and formulation2026
Aprepitant: Review on Solubility Enhancement.
Review in Recent advances in drug delivery and formulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
introductionSubstance P and its neurokinin (NK-1) receptors are upregulated in different pathophysiological conditions. Overexpression of the NK-1 receptor in cancer conditions has provided a promising pathway for cancer treatment. Clinically, Aprepitant (APT) is used as the only NK-1 antagonist in chemotherapy-induced nausea and vomiting (CINV). Currently, investigations into using APT as a synergistic combination with radiation or standard chemotherapeutic drugs are underway. However, APT is categorised as a BCS Class IV drug, and therefore, solubility is one of the challenges when it must be delivered parenterally. The present review aims to understand the solubility enhancement techniques for better bioavailability.
methodsResearch and review articles were sought to understand the chemistry and solubility enhancement techniques reported for APT. Search engines such as Science Direct, PubMed, Bentham, and Google Scholar were used with the keywords "Aprepitant, solubility, NK1 receptor, parenteral dosage form."
resultsThe review comprehensively discusses the methods to improve the solubility of APT using innovative technologies, including nanotechnology. DISCUSSION: The review highlights the challenges associated with the use of APT in treating chemotherapy- induced nausea and vomiting (CINV), as well as its potential as a promising anticancer agent. While various solubility enhancement techniques can be employed for the oral administration of APT, the appropriate use of excipients and stability are essential for its safe clinical use in parenteral dosage forms.
conclusionThe available solubility enhancement techniques discussed come with benefits and limitations. Fosaprepitant, a prodrug, is preferably used as an IV dosage form. Similarly, modification to a prodrug and solubility-enhancing excipients for nanoformulation can help make APT a promising therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.