ArticleBMC veterinary research2025
Immunologic response to first booster vaccination in dogs treated with zenrelia™ (ilunocitinib tablets) at up to three times the recommended therapeutic dose compared to untreated controls.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Anti-Cytokine Drugs in the Treatment of Canine Atopic Dermatitis.International journal of molecular sciences · 2025Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis prospective, non-inferiority study was designed to evaluate the serologic response to booster vaccination in dogs previously vaccinated according to standard of care practice and treated for 56 days with up to 3X the recommended label dose of ilunocitinib. Vaccination occurred 28 days post-treatment initiation and continued through day 56. Measured study parameters included: vaccine-induced serum antibody titers at 15- and 28-day post-vaccination, along with hematological and clinical chemistry parameters.
resultsSerum antibody titer levels were not significantly different between the control and ilunocitinib treated groups (1X and 3X), and both met the non-inferiority criteria versus the control group after 56 days of treatment (SD 56). All dogs administered ilunocitinib had titers at or above threshold for rabies, CAV-2, and CPV at 15- and 28-day post-vaccination timepoints (SD 43 and SD 56, respectively). The percentage of dogs with titers at or above threshold on SD 43 for CDV were 96, 100, and 95% in the control, 1X and 3X groups, respectively. By SD 56, the percentage of animals with titers above threshold for CDV were similar to pre-vaccination levels in all groups.
conclusionThis study demonstrated treatment with ilunocitinib at 1X or 3X the therapeutic dose for 56 days did not significantly attenuate the serologic response to CAV-2, CPV, CDV or rabies booster vaccinations compared to untreated control animals. All animals remained clinically healthy during the study, with only mild gastrointestinal or skin abnormalities typical of laboratory dogs or JAK inhibitor therapy.
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