Observational studyBMC health services research2025
Burden of chronic spontaneous urticaria in Italy through healthcare resource utilization and direct costs: a retrospective analysis of real-world using administrative healthcare data.
Observational study in BMC health services research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Chronic Spontaneous Urticaria in Finland - A Nationwide Registry Study on Epidemiology and Treatment Patterns in Secondary Care.Acta dermato-venereologica · 2026Article
- Hypoparathyroidism: clinical profiles, healthcare use, and costs from real-world data from Italy.Endocrine connections · 2026Article
- The societal costs associated with patients with chronic spontaneous urticaria (CSU) in Italy.Global & regional health technology assessmentArticle
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic spontaneous urticaria (CSU) is a disorder of skin and mucosal tissues lasting at least 6 weeks. Treatments are primarily addressed to reduce symptoms; therefore, patients still experience poor living conditions and high unmet needs. This retrospective observational study was aimed to describe patients newly diagnosed with CSU, their healthcare resource utilization and related economic burden through Italian administrative healthcare data.
methodsFrom a large Italian administrative healthcare database (˜5.5 million inhabitants/year), in- and outpatients newly diagnosed with CSU from January 1
resultsPatients newly diagnosed with CSU in Italy were 1,707. The median (IQR) age was 36 (18;55) years with twice as many females as males. Cardiometabolic diseases were the most common comorbidities. Throughout the first follow-up year: 72.9% patients were treated with second-generation H1-antihistamines (mainly cetirizine), 19.5% with omalizumab; concomitantly, 55.5% received oral corticosteroids (OCS), and 25.0% non-steroidal antiinflammatory drugs. At least one CSU exacerbation occurred in 81.2% patients; of them, only one third were treated with omalizumab on average 10.9 months following exacerbation. New users of omalizumab during the available follow-ups were 30.6% patients. On average, 1.6 overnight hospitalizations occurred to 16.8% of patients mainly because of urticaria and angioedema. At least one local outpatient specialist service was performed to 78.6% patients; 63.3% were examined by a specialist, on average 3 times during the first year. The mean per patient annual total expenditure was €1901, of which 45.4% was due to pharmaceuticals.
conclusionsDuring the first year following the new CSU diagnosis, a lower than recommended antihistamines dispensation while an elevated use of OCS and a low and delayed omalizumab initiation after CSU exacerbation were observed, suggesting the urgent need to optimize treatment management to limit the burden on patients and healthcare systems.
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