Evidence map›Paper›PMID 40696247›Full record

ArticleInvestigational new drugs2025

Design and optimization of PLGA-based gemcitabine nanocapsule for enhanced pancreatic cancer efficacy.

Gaurav Tiwari, Satyajit Panda, A Salomy Monica Diyya, Noel Vinay Thomas, Trinayan Deka, Shashi Ravi Suman Rudrangi, Gaurav Patel, Pankaj Sharma

Abstract read
PubMed Publisher
In one paragraph

Article in Investigational new drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Tumor-Targeted Delivery Therapy Based on PLGA Nanoparticles.Journal of functional biomaterials · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gaurav TiwariPSIT-Pranveer Singh Institute of Technology (Pharmacy), Kanpur-Agra-Delhi National, NH 19, Kanpur, Uttar Pradesh, 209305, India.ORCID 0000-0003-2200-737X
Satyajit PandaDepartment of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha, 754202, India.ORCID 0000-0002-6184-6152
A Salomy Monica DiyyaDepartment of Pharmacy, College of Medicine, Komar University of Science and Technology, Sulaymaniyah, Kurdistan, Iraq.ORCID 0000-0002-0783-0686
Noel Vinay ThomasDepartment of Biomedical Sciences, College of Science, Komar University of Science and Technology, Sulaymaniyah, Kurdistan Region, Iraq.ORCID 0000-0002-3750-0653
Trinayan DekaFaculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Guwahati, Assam, India.ORCID 0000-0002-2898-8810
Shashi Ravi Suman RudrangiKent Pharma UK Limited, Second Floor, Connect 38, 1 Dover Place, Ashford County/District: Kent, UK.ORCID 0000-0002-2162-9276
Gaurav PatelAnalytical Chemistry, Sigmapharm Laboratories, Bensalem, USA.ORCID 0009-0002-7594-6717
Pankaj SharmaDepartment of Pharmaceutics, ShriRam College of Pharmacy, Morena-476444, Banmore, Madhya Pradesh, India. pankajsharma223@gmail.com.ORCID 0000-0003-0211-9606

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to develop gemcitabine-loaded nanocapsules for pancreatic cancer treatment, optimizing their formulation before evaluating them through in vivo studies. The researchers selected gemcitabine as the model drug because it has established clinical relevance and known pharmacokinetic shortfalls (short half-life and poor bioavailability) with toxic dose limits which suit the evaluation of nanoparticle drug delivery systems. The researchers conducted a 3

Indexed as

Antimetabolites, AntineoplasticDeoxycytidineLactic AcidNanocapsulesPancreatic NeoplasmsPolyglycolic AcidAnimalsBiological AvailabilityCell Line, TumorDrug CarriersDrug LiberationGemcitabineHumansMaleMicePolylactic Acid-Polyglycolic Acid CopolymerAntimetabolites, AntineoplasticDeoxycytidineDrug CarriersGemcitabineLactic AcidNanocapsulesPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerDrug deliveryEncapsulation efficiencyGemcitabineIn vivo evaluationNanocapsulesPancreatic cancer

Identifiers

PMID40696247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.