ArticleCommunications biology2025
The role of neonatal kisspeptin in long-term social behavior in mammals.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Kisspeptins (Kiss) are key regulators of the hypothalamic-pituitary-gonadal axis, influencing testosterone surges essential for brain masculinization and behavioral development in mammals. This study explored the effects of transient neonatal Kiss blockade on long-term social behaviors in Wistar rats. Newborn rats of both sexes were injected with either a Kiss antagonist or vehicle during the postnatal testosterone surge, termed "minipuberty". In adolescence and adulthood, social behaviors, hypothalamic Kiss receptor levels, and serum levels of Gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), testosterone, and follicle-stimulating hormone (FSH) were assessed. Results showed that neonatal Kiss modulates testosterone differently in males and females, influencing social communication and long-term social skills. Increased exploratory behavior was observed, with males exhibiting heightened sexual impulsiveness without anxiety changes. Altered hypothalamic-pituitary-gonadal hormone levels due to Kiss blockade may help explain some results. These findings highlight the critical role of neonatal Kiss in shaping lifelong social interactions and communication in a sex-dependent manner.
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