Evidence map›Paper›PMID 40696166›Full record

ArticlePediatric cardiology2026

Relationship Between Central Venous Pressure, Cardiac Index, and Renal Function in Pediatric Heart Failure: a Pediatric Heart Transplant Society Study.

Nilay Donmez, Marva Moxey-Mims, Ryan Cantor, Maryanne R Chrisant, David W Bearl, Nathanya Baez Hernandez, John Dykes, Gary S Beasley, Gerard Boyle, Shriprasad R Deshpande

Abstract read
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Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nilay DonmezDivision of Pediatric Nephrology, Children's National Hospital, Washington, DC, 20010, USA.
Marva Moxey-MimsDivision of Pediatric Nephrology, Children's National Hospital, Washington, DC, 20010, USA.
Ryan CantorKirklin Solutions, Pediatric Heart Transplant Society, Birmingham, AL, USA.
Maryanne R ChrisantJoe DiMaggio Children's Hospital Heart Institute, Hollywood, FL, USA.
David W BearlMonroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
Nathanya Baez HernandezChildren's Health, UT Southwestern Medical Center, Dallas, TX, USA.
John DykesLucile Packard Children's Hospital, Stanford University, Palo Alto, CA, USA.
Gary S BeasleyStead Family Children's Hospital, University of Iowa, Iowa City, IA, USA.
Gerard BoyleChildren's Institute, Cleveland Clinic, Cleveland, OH, USA.
Shriprasad R DeshpandeDivision of Pediatric Cardiology, Advanced Cardiac Therapies Program, Children's National Hospital, 111, Michigan Ave NW, Washington, DC, 20010, USA. sdeshpan@childrensnational.org.ORCID http://orcid.org/0000-0002-8358-9783

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal dysfunction (RD) is common in patients with heart failure with or without congenital heart disease, but the determinants of renal dysfunction are not well understood in children with heart failure. Low cardiac output is often discussed as a risk factor for RD.The purpose of this study was therefore to elucidate the relationship between renal function and hemodynamic parameters in children with heart failure. Children (age < 18, n = 3739) listed for HT in the PHTS database from 1993-2023 were included. Laboratory, clinical, hemodynamic, and demographic parameters were collected and analyzed for the study. RD was defined as eGFR less than 40 ml/min/1.73 m2 for patients younger than 2 years old, less than 60 ml/min/1.73 m2 for patients 2 years old and older. We assessed correlation between eGFR and hemodynamic parameters. Logistic regression was used to assess risk factors for renal dysfunction by etiologic cohort. The mean age was 7.2 ± 6.2 years, weight 27.78 ± 25.03 kg, male gender 58%, 39% with cardiomyopathy (CM) and 61% with congenital heart disease (CHD) including 21% with Fontan circulation. RD was present in 6% of the cohort.In CM cohort, high BMI (OR 1.057, 1.025-1.091), male gender (OR 2.08, 1.21-3.59), black race (OR 1.98, 1.17-3.36) and heart failure category of high cardiac index with high CVP compared to high cardiac index with low CVP (OR 2.34, 1.27-4.29) were significant predictors of renal dysfunction.In Fontan cohort, only BMI (OR 1.08, CI 1.023-1.134) was associated with renal dysfunction while none of the hemodynamic parameters predicted RD in CHD cohort.Lastly, RD at listing (OR 2.82, CI 1.50-5.28), weight at transplant (OR 1.00, CI 1.00-1.01), post-transplant mechanical circulatory support (OR 2.55, CI 1.04-6.26), and post-transplant dialysis (2.74, CI 1.106.84) were associated with RD at one-year post-transplant for the overall cohort. The relationship between various clinical and hemodynamic factors and renal dysfunction is complex in children with heart failure. Further, the study continued to show persistent impact of renal dysfunction at listing on post-transplant renal function. Improving understanding modifiable risk factors by type of heart disease as well as role of newer heart failure therapies is critical in reducing this significant morbidity.

Indexed as

Central Venous PressureGlomerular Filtration RateHeart FailureHeart TransplantationKidneyAdolescentChildChild, PreschoolFemaleHeart Defects, CongenitalHemodynamicsHumansInfantMaleRetrospective StudiesRisk FactorsCardiorenal syndromeHeart failureOutcomesPediatric cardiologyRenal dysfunctionVenous congestion

Identifiers

PMID40696166

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.