Evidence map›Paper›PMID 40696163›Full record

ArticleCommunications biology2025

Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions.

Léo Michel, Denys Osypenko, Patricia Molina, Kadir A Mutlu, Salvatore Lecca, Chihiro Hisatsune, Katsuhiko Mikoshiba, Toko Kikuchi, Emre Yaksi, Andrea Volterra and 1 more

Abstract read
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In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Léo MichelThe Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-6688-5708
Denys OsypenkoThe Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.
Patricia MolinaThe Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.
Kadir A MutluKavli Institute for Systems Neuroscience and Center for Algorithms in the Cortex, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0003-1318-6425
Salvatore LeccaThe Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-5411-5485
Chihiro HisatsuneCalpain Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7811-7784
Katsuhiko MikoshibaShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0002-3487-6970
Toko KikuchiWyss Center for Bio and Neuro Engineering, Campus Biotech, Geneva, Switzerland.ORCID http://orcid.org/0009-0008-6482-5964
Emre YaksiKavli Institute for Systems Neuroscience and Center for Algorithms in the Cortex, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0003-3761-0235
Andrea VolterraThe Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.
Manuel MameliThe Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland. manuel.mameli@unil.ch.ORCID http://orcid.org/0000-0002-0570-6964

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_212193
6 · The paper itself

Abstract

Behavioral challenges prompt alternating vigorous and reduced mobility - active, passive coping - that optimize energy investment. Here, we show that disrupting astrocytes calcium signaling in the mouse lateral habenula (LHb) prolongs active coping. This state manifests through calcium elevations in both mouse and zebrafish habenular astrocytes. Presynaptic tracing approaches integrate LHb astrocytes within aversion-related neuronal circuits. Thus, astrocytes regulate state transitions highlighting their computational contribution to behaviors across species.

Indexed as

Adaptation, PsychologicalAstrocytesBehavior, AnimalCalciumCalcium SignalingHabenulaAnimalsMaleMiceMice, Inbred C57BLZebrafishCalcium

Identifiers

PMID40696163
PMCPMC12284069

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.