ReviewNature reviews. Immunology2025
Uterine inflammation and lessons from large animal models of endometritis.
Review in Nature reviews. Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Development of Mucoadhesive Nanofiber as an Alternate Therapeutic Regimen for Subclinical Endometritis in Cattle.Turkish journal of pharmaceutical sciences · 2026Article
- Identification of reproductive and molecular biomarkers associated with clinical metritis in dromedary camels (Frontiers in veterinary science · 2026Article
- Microalgae as a prospective antibiotic replacement therapy for induced endometritis in rats through regulating inflammatory cytokines.Journal of advanced veterinary and animal research · 2026Article
- Involvement of chemokine CXCL12 and its receptor CXCR4 in uterine receptivity and potential relationship to fertility in cattle: a mini review.Frontiers in veterinary science · 2025Review
- Linking the Warburg effect to endometrial receptivity: metabolic parallels in embryo implantation.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uterine inflammation encompasses several conditions, including endometritis, which is a local innate immune response, usually to bacteria. Endometritis is an important veterinary and medical problem that can result in infertility and/or recurrent pregnancy loss. This Review aims to summarize animal models that can be used to uncover the immune pathways responsible for uterine inflammation and their value for screening novel, putative therapies. We discuss large animal models of endometritis, particularly the well-used bovine system and the value that may be added by further developing porcine systems. Animal cells and tissue explants can be ethically sourced, and these models can replace or reduce the need for live animal studies and overcome the practical issues of harvesting endometrial material from women. We explain how these models of endometritis show great potential for advancing our understanding of the immune dysfunction underlying susceptibility to the condition, and for early-stage drug discovery.
Indexed as
Identifiers
40696155What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.