Evidence map›Paper›PMID 40696140›Full record

ArticleNPJ precision oncology2025

Development of a deep learning model for T1N0 gastric cancer diagnosis using 2.5D radiomic data in preoperative CT images.

Jingyang He, Jingli Xu, Wujie Chen, Mengxuan Cao, Jiaqing Zhang, Qing Yang, Enze Li, Ruolan Zhang, Yahang Tong, Yanqiang Zhang and 8 more

Abstract read
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Artificial intelligence models in predicting lymph node metastasis in early gastric cancer: a systematic review and meta -analysis.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jingyang He *Department of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Jingli Xu *Department of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Wujie Chen *Department of Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Mengxuan CaoDepartment of Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Jiaqing ZhangDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Qing YangDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Enze LiDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Ruolan ZhangDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Yahang TongDepartment of Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Yanqiang ZhangDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Chen GaoZhejiang Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China.
Qianyu ZhaoDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Zhiyuan XuDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Lijing WangDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Xiangdong ChengDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Guoliang ZhengDepartment of Gastric Surgery, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China. zhengboren1@126.com.
Siwei PanDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. pansw@zjcc.org.cn.
Can HuDepartment of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. hucan@zjcc.org.cn.

Funding

National Natural Science Foundation of China 82304946National Natural Science Foundation of China 82403546National Natural Science Foundation of China 82473489Natural Science Foundation of Zhejiang Province MS25H160146Post-doctoral Innovative Talent Support Program BX2023375The Medicine and Health Science Fund of Zhejiang Province 2025KY047The National Key Research and Development Program of China 2021YFA0910100
6 · The paper itself

Abstract

Early detection and precise preoperative staging of early gastric cancer (EGC) are critical. Therefore, this study aims to develop a deep learning model using portal venous phase CT images to accurately distinguish EGC without lymph node metastasis. This study included 3164 patients with gastric cancer (GC) who underwent radical surgery at two medical centers in China from 2006 to 2019. Moreover, 2.5D radiomic data and multi-instance learning (MIL) were novel approaches applied in this study. By basing the selection of features on 2.5D radiomic data and MIL, the ResNet101 model combined with the XGBoost model represented a satisfactory performance for diagnosing pT1N0 GC. Furthermore, the 2.5D MIL-based model demonstrated a markedly superior predictive performance compared to traditional radiomics models and clinical models. We first constructed a deep learning prediction model based on 2.5D radiomics and MIL for effectively diagnosing pT1N0 GC patients, which provides valuable information for the individualized treatment selection.

Identifiers

PMID40696140
PMCPMC12284126

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.