ArticleCommunications medicine2025
Iron homeostasis and cytokine responses in Gabonese children with febrile illness.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03047642 (Validation of Promising Biomarker Assays to Assess Their Diagnostic Performance Characteristics in Africa and Latin America), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Validation of Promising Biomarker Assays to Assess Their Diagnostic Performance Characteristics in Africa and Latin America
Who cites it
1 citing paper in PubMed.
- Iron homeostasis and cytokine responses in Gabonese children with febrile illness.Communications medicine · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIron deficiency, anemia, and infectious diseases contribute largely to the disease burden among children in Sub-Saharan Africa. Accurate assessment of iron status and its relationship with infections is essential for refining iron supplementation strategies.
methodsWe report retrospectively analyzed data from a cross-sectional study of children aged 2-17 years with acute febrile illness (fever ≤7 days) in Lambaréné, Gabon (NCT03047642). Symptom-based microbiological testing identified infection etiology. Blood count, C-reactive protein, iron parameters, and cytokines levels assessed iron deficiency, anemia, and immune activation.
resultsAmong 415 screened children with acute febrile illness, hemoglobin and iron parameters are available in 197. Of those, 145 (73.6%) are anemic: 53 (36.6%) show anemia of inflammation (AI), 11 (7.6%) iron-deficiency anemia (IDA), and 29 (20.0%) combined AI/IDA. Others are categorized as multifactorial, with mostly microcytic anemia, transferrin saturation (TSAT) ≥ 20% and varying ferritin levels. TSAT is negatively associated with IL-10, IL-6, and IL-2 in the malaria-positive group, with IL-10 also showing a positive correlation with parasitemia counts. In malaria-negative children with undetermined pathogens, IFN-γ and IL-4 levels are positively associated with TSAT and ferritin.
conclusionsThese findings highlight iron dyshomeostasis in infectious diseases and confirm associations between iron availability and immune activation to causative pathogens.
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Registered trials
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