Articlenpj antimicrobials and resistance2025
Pan-genus analysis and typing of antimicrobial resistance plasmids in Acinetobacter.
Article in npj antimicrobials and resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- The (un)successful global spread ofMicrobial genomics · 2026Article
- Emergence ofMicrobiology spectrum · 2026Article
- The population structure ofApplied and environmental microbiology · 2026Article
- Variations in plasmid transfer inMicrobiology spectrum · 2026Article
- Phenotypic and genotypic characterization ofOne health (Amsterdam, Netherlands) · 2026Article
- Analysis of clinical characteristics and whole-genome sequencing of carbapenem-resistant Acinetobacter baumannii isolates from pediatric patients in Guangxi, China.BMC microbiology · 2026Article
- Cattle feces are a reservoir of diverse Acinetobacter species with potential to spread antibiotic resistance genes.Animal microbiome · 2026Article
- Genomic Epidemiology of NDM-1 Carbapenemase-ProducingAntibiotics (Basel, Switzerland) · 2026Article
- DiverseMicrobiology spectrum · 2026Article
- The therapeutic potential of phage pT2784 against ST40-KL47 typeMicrobiology spectrum · 2026Article
- Article
- Mosquitoes as vector-based sentinels for tracking bacterial pathogens and antimicrobial resistance in the environment.Frontiers in microbiology · 2026Review
- Article
- Global emergence ofMicrobial genomics · 2025Article
- The Road Less Traveled: Exploring the Genomic Characteristics and Antimicrobial Resistance Potential of Acinetobacter baumannii From the Indigenous Orang Asli Community in Peninsular Malaysia.MicrobiologyOpen · 2025Article
- Genome-wide identification and expression profiling of bHLH transcription factors associated with ferulic acid biosynthesis inFrontiers in plant science · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Plasmids play a central role in horizontal gene transfer and bacterial adaptation, especially in the context of antimicrobial resistance (AMR) among opportunistic pathogens. Some members of the genus Acinetobacter are known for their role in hospital-acquired infections, harboring plasmids that facilitate rapid adaptation to selective pressures. However, the extent of plasmid diversity and evolutionary dynamics within Acinetobacter has not been fully elucidated. In this study, we analysed 1846 complete and non-redundant Acinetobacter plasmid sequences, identifying 166 novel Replicase (Rep) protein types and providing a significant update to the Acinetobacter Plasmid Typing (APT) scheme, which now comprises 257 Rep types. A detailed phylogenetic analysis of the prevailing R3-type Rep sequences reveals two distinct evolutionary clades (A and B) and several additional subclades. This phylogenetic structure suggests evolutionary pressures within all clades, potentially influenced by host species distribution and environmental factors. Analysis of these plasmids highlights diverse plasmid types involved in dissemination of AMR within the genus in different niches, underscoring both clinical and natural environments as reservoirs of Acinetobacter plasmids. Our findings provide a refined framework for tracking Acinetobacter plasmids, advancing our understanding of plasmid-mediated AMR spread and informing strategies to combat the spread of AMR in this critical genus.
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Registered trials
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